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Article Dans Une Revue Bioconjugate Chemistry Année : 2019

Dendrimer-Enabled Therapeutic Antisense Delivery Systems as Innovation in Medicine

Résumé

Antisense oligonucleotide (AON)-based therapies concern the treatment for genetic disorders or infections such as a range of neurodegenerative and neuromuscular diseases and have shown benefits in animal models and patients. Nevertheless, successes in the clinic are still strongly limited by unfavorable biodistribution and poor cellular uptake of AONs. Dendrimer macromolecules are synthetically accessible and consist of a core with repeated iterations (named branches) surrounding this core, and on the periphery functional groups which can be modified for ligand attachment. The generations of these branched nanoparticles are based on the number of branches emanating from the core with layered architectures. Dendrimers show promise in several biomedical applications based on their tunable surface modifications allowing the adjustment of their in vivo behavior related to biocompatibility and pharmacokinetic parameters. Dendrimers can be used as nanocarriers of various types of drugs including AONs or nanodrugs. As nanocarriers, polycationic dendrimers can complex multiple negatively charged DNA oligonucleotides on their surface and form stable complexes to promote internalization into the cells based on a good cell membrane affinity. These nanocarriers complexing antisense oligonucleotides must be stable enough to reach the cellular target, but with adequate in vivo global clearance, and have good pharmacokinetic (PK) and pharmacodynamic (PD) profiles. This Review was designed to analyze the development of AONs carried by polycationic and polyanionic (few example) dendrimers. This Review strongly supports the idea that dendrimers, with adequate modulation of their terminal groups, could be used to carry AONs in cells.
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Dates et versions

hal-03274556 , version 1 (30-06-2021)

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Serge Mignani, Xiangyang Shi, Maria Zablocka, Jean-Pierre Majoral. Dendrimer-Enabled Therapeutic Antisense Delivery Systems as Innovation in Medicine. Bioconjugate Chemistry, 2019, 30 (7), pp.1938-1950. ⟨10.1021/acs.bioconjchem.9b00385⟩. ⟨hal-03274556⟩
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