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Journal Articles Current Biology - CB Year : 2000

Blood coagulation: The outstanding hydrophobic residues

Abstract

Newly determined crystal structures suggest that the membrane-binding C2 domains of blood coagulation cofactors Va and VIIIa bind anionic phospholipids through protruding solvent-exposed hydrophobic residues, aided by a crown of positively charged residues and by specific hydrogen-bonding side chains.

Dates and versions

hal-03274034 , version 1 (29-06-2021)

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Jean-Luc Pellequer, Andrew J Gale, Elizabeth D Getzoff. Blood coagulation: The outstanding hydrophobic residues. Current Biology - CB, 2000, 10 (6), pp.R237-R240. ⟨10.1016/S0960-9822(00)00373-0⟩. ⟨hal-03274034⟩
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