Effects of a Mindfulness-Based Intervention versus Health Self-Management on Subclinical Anxiety in Older Adults with Subjective Cognitive Decline: The SCD-Well Randomized Superiority Trial - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Psychotherapy and Psychosomatics Année : 2021

Effects of a Mindfulness-Based Intervention versus Health Self-Management on Subclinical Anxiety in Older Adults with Subjective Cognitive Decline: The SCD-Well Randomized Superiority Trial

Natalie L. Marchant
  • Fonction : Auteur
Thorsten Barnhofer
  • Fonction : Auteur
Miranka Wirth
  • Fonction : Auteur
Fabienne Collette
  • Fonction : Auteur
Harriet Demnitz-King
  • Fonction : Auteur
Ann-Katrin Schild
  • Fonction : Auteur
Nina Coll-Padros
  • Fonction : Auteur
Floriane Delphin-Combe
  • Fonction : Auteur
Tim Whitfield
  • Fonction : Auteur
Marco Schlosser
  • Fonction : Auteur
Julie Gonneaud
  • Fonction : Auteur
Julien Asselineau
  • Fonction : Auteur
Zuzana Walker
  • Fonction : Auteur
Pierre Krolak-Salmon
  • Fonction : Auteur
Jose Luis Molinuevo
  • Fonction : Auteur
Eric Frison
Frank Jessen
  • Fonction : Auteur
Olga M. Klimecki
  • Fonction : Auteur

Résumé

INTRODUCTION: Older adults experiencing subjective cognitive decline (SCD) have a heightened risk of developing dementia and frequently experience subclinical anxiety, which is itself associated with dementia risk. OBJECTIVE: To understand whether subclinical anxiety symptoms in SCD can be reduced through behavioral interventions. METHODS: SCD-Well is a randomized controlled trial designed to determine whether an 8-week mindfulness-based intervention (caring mindfulness-based approach for seniors; CMBAS) is superior to a structurally matched health self-management program (HSMP) in reducing subclinical anxiety. Participants were recruited from memory clinics at 4 European sites. The primary outcome was change in anxiety symptoms (trait subscale of the State-Trait Anxiety Inventory; trait-STAI) from pre- to postintervention. Secondary outcomes included a change in state anxiety and depression symptoms postintervention and 6 months postrandomization (follow-up). RESULTS: One hundred forty-seven participants (mean [SD] age: 72.7 [6.9] years; 64.6% women; CMBAS, n = 73; HSMP, n = 74) were included in the intention-to-treat analysis. There was no difference in trait-STAI between groups postintervention (adjusted change difference: -1.25 points; 95% CI -4.76 to 2.25) or at follow-up (adjusted change difference: -0.43 points; 95% CI -2.92 to 2.07). Trait-STAI decreased postintervention in both groups (CMBAS: -3.43 points; 95% CI -5.27 to -1.59; HSMP: -2.29 points; 95% CI -4.14 to -0.44) and reductions were maintained at follow-up. No between-group differences were observed for change in state anxiety or depression symptoms. CONCLUSIONS: A time-limited mindfulness intervention is not superior to health self-management in reducing subclinical anxiety symptoms in SCD. The sustained reduction observed across both groups suggests that subclinical anxiety symptoms in SCD are modifiable. ClinicalTrials.gov identifier: NCT03005652.
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hal-03273712 , version 1 (29-06-2021)

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Paternité - Pas d'utilisation commerciale

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Natalie L. Marchant, Thorsten Barnhofer, Roxane Coueron, Miranka Wirth, Antoine Lutz, et al.. Effects of a Mindfulness-Based Intervention versus Health Self-Management on Subclinical Anxiety in Older Adults with Subjective Cognitive Decline: The SCD-Well Randomized Superiority Trial. Psychotherapy and Psychosomatics, In press, ⟨10.1159/000515669⟩. ⟨hal-03273712⟩
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