Electrical stimulation for seizure induction during SEEG exploration: a useful predictor of postoperative seizure recurrence? - Archive ouverte HAL
Article Dans Une Revue Journal of Neurology, Neurosurgery and Psychiatry Année : 2020

Electrical stimulation for seizure induction during SEEG exploration: a useful predictor of postoperative seizure recurrence?

Agnes Trebuchon
Renata Racila
  • Fonction : Auteur
Francesco Cardinale
  • Fonction : Auteur
Aileen Mcgonigal
Giorgio Lo Russo
  • Fonction : Auteur
Didier Scavarda
Romain Carron
Roberto Mai
  • Fonction : Auteur
Patrick Chauvel
Fabrice Bartolomei
Stefano Francione
  • Fonction : Auteur

Résumé

Objective Direct electrical stimulations of cerebral cortex are a traditional part of stereoelectroencephalography (SEEG) practice, but their value as a predictive factor for seizure outcome has never been carefully investigated. Patients and method We retrospectively analysed a cohort of 346 patients operated on for drug-resistant focal epilepsy after SEEG exploration. As potential predictors we included: aetiology, MRI data, age of onset, duration of epilepsy, age at surgery, topography of surgery and whether a seizure was induced by either low frequency electrical stimulation (LFS) or high frequency electrical stimulation. Results Of 346 patients, 63.6% had good outcome (no seizure recurrence, Engel I). Univariate analysis demonstrated significant correlation with favourable outcome (Engel I) for: aetiology, positive MRI and seizure induced by stimulation. At multivariate analysis, informative MRI, type II focal cortical dysplasia and tumour reduced the risk of seizure recurrence (SR) by 47%, 58% and 81%, respectively. Compared with the absence of induced seizures, the occurrence of ictal events after LFS significantly predicts a favourable outcome on seizures, with only 44% chance of disabling SR at last follow-up. Conclusion Among the already known predictors outcome, seizure induction by LFS therefore represents a positive predictive factor for seizure outcome after surgery.

Domaines

Neurosciences
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Dates et versions

hal-03273626 , version 1 (29-06-2021)

Identifiants

Citer

Agnes Trebuchon, Renata Racila, Francesco Cardinale, Stanislas Lagarde, Aileen Mcgonigal, et al.. Electrical stimulation for seizure induction during SEEG exploration: a useful predictor of postoperative seizure recurrence?. Journal of Neurology, Neurosurgery and Psychiatry, 2020, 92 (1), pp.22-26. ⟨10.1136/jnnp-2019-322469⟩. ⟨hal-03273626⟩
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