<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03272295</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-16T13:17:19+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Glutamate optimizes enzymatic activity under high hydrostatic pressure in Desulfovibrio species: effects on the ubiquitous thioredoxin system</title>
            <author role="aut">
              <persName>
                <forename type="first">Hélène</forename>
                <surname>Gaussier</surname>
              </persName>
              <email type="md5">8bb9211aa31b1da9fd377a5518d10ef6</email>
              <email type="domain">univ-amu.fr</email>
              <idno type="idhal" notation="string">helene-gaussier</idno>
              <idno type="idhal" notation="numeric">173279</idno>
              <idno type="halauthorid" notation="string">37259-173279</idno>
              <affiliation ref="#struct-191652"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M.</forename>
                <surname>Nouailler</surname>
              </persName>
              <email type="md5">fb715ef31650c04ce86f82d231739c3c</email>
              <email type="domain">univ-amu.fr</email>
              <idno type="idhal" notation="string">matthieu-nouailler</idno>
              <idno type="idhal" notation="numeric">744737</idno>
              <idno type="halauthorid" notation="string">7655-744737</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2061-466X</idno>
              <idno type="IDREF">https://www.idref.fr/112669565</idno>
              <affiliation ref="#struct-472"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Edouard</forename>
                <surname>Champaud</surname>
              </persName>
              <idno type="halauthorid">2241133-0</idno>
              <affiliation ref="#struct-191652"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Edwige</forename>
                <surname>Garcin</surname>
              </persName>
              <idno type="halauthorid">1128245-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sebban</forename>
                <surname>-Kreuzer</surname>
              </persName>
              <email type="md5">1d1ca48aad66f668fe378b163146c200</email>
              <email type="domain">imm.cnrs.fr</email>
              <idno type="idhal" notation="string">corinne-sebban-kreuzer</idno>
              <idno type="idhal" notation="numeric">747092</idno>
              <idno type="halauthorid" notation="string">2238032-747092</idno>
              <idno type="IDREF">https://www.idref.fr/169718034</idno>
              <affiliation ref="#struct-198056"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Olivier</forename>
                <surname>Bornet</surname>
              </persName>
              <email type="md5">b01ede3d0472ab5cec6694c81fb9fe48</email>
              <email type="domain">imm.cnrs.fr</email>
              <idno type="idhal" notation="string">olivier-bornet</idno>
              <idno type="idhal" notation="numeric">1075953</idno>
              <idno type="halauthorid" notation="string">386571-1075953</idno>
              <affiliation ref="#struct-186491"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marc</forename>
                <surname>Garel</surname>
              </persName>
              <email type="md5">bb2eb6c5c9c8841d9ac80b2c6fc86178</email>
              <email type="domain">mio.osupytheas.fr</email>
              <idno type="idhal" notation="string">marc-garel</idno>
              <idno type="idhal" notation="numeric">21552</idno>
              <idno type="halauthorid" notation="string">16260-21552</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4374-5905</idno>
              <idno type="IDREF">https://www.idref.fr/253133009</idno>
              <affiliation ref="#struct-191652"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christian</forename>
                <surname>Tamburini</surname>
              </persName>
              <email type="md5">0a937568f7697ae8eae77dfb232661ed</email>
              <email type="domain">univmed.fr</email>
              <idno type="idhal" notation="string">christiantamburini</idno>
              <idno type="idhal" notation="numeric">20223</idno>
              <idno type="halauthorid" notation="string">26048-20223</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/I-7821-2012</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3752-7423</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.nl/citations?user=LNVxm1UAAAAJ&amp;hl=fr</idno>
              <idno type="IDREF">https://www.idref.fr/069965625</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/I-7821-2012</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laetitia</forename>
                <surname>Pieulle</surname>
              </persName>
              <email type="md5">bb8ffbdba4e903532aef269c6f2fca9e</email>
              <email type="domain">imm.cnrs.fr</email>
              <idno type="idhal" notation="string">laetitia-pieulle</idno>
              <idno type="idhal" notation="numeric">1021199</idno>
              <idno type="halauthorid" notation="string">452532-1021199</idno>
              <affiliation ref="#struct-479"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alain</forename>
                <surname>Dolla</surname>
              </persName>
              <email type="md5">b1f2dea5f3af40edbe62486b4459afa7</email>
              <email type="domain">mio.osupytheas.fr</email>
              <idno type="idhal" notation="string">alain-dolla</idno>
              <idno type="idhal" notation="numeric">20181</idno>
              <idno type="halauthorid" notation="string">4915-20181</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2930-1336</idno>
              <idno type="IDREF">https://www.idref.fr/084131128</idno>
              <affiliation ref="#struct-191652"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nathalie</forename>
                <surname>Pradel</surname>
              </persName>
              <email type="md5">aea9180acb387cc93ce4768ada5bfc81</email>
              <email type="domain">univ-amu.fr</email>
              <idno type="idhal" notation="string">nathalie-pradel</idno>
              <idno type="idhal" notation="numeric">19909</idno>
              <idno type="halauthorid" notation="string">16272-19909</idno>
              <affiliation ref="#struct-191652"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Alain</forename>
                <surname>Dolla</surname>
              </persName>
              <email type="md5">b1f2dea5f3af40edbe62486b4459afa7</email>
              <email type="domain">mio.osupytheas.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2021-06-28 11:36:42</date>
              <date type="whenModified">2026-04-02 11:14:01</date>
              <date type="whenReleased">2021-07-01 11:43:24</date>
              <date type="whenProduced">2021</date>
              <date type="whenEndEmbargoed">2021-06-28</date>
              <ref type="file" target="https://hal.science/hal-03272295v1/document">
                <date notBefore="2021-06-28"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-03272295v1/file/version%20accepte-hal.pdf" id="file-3272295-2878195">
                <date notBefore="2021-06-28"/>
              </ref>
              <ref type="externalLink" target="https://hal.archives-ouvertes.fr/hal-03272295/file/version%20accepte-hal.pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="622271">
                <persName>
                  <forename>Alain</forename>
                  <surname>Dolla</surname>
                </persName>
                <email type="md5">b1f2dea5f3af40edbe62486b4459afa7</email>
                <email type="domain">mio.osupytheas.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03272295</idno>
            <idno type="halUri">https://hal.science/hal-03272295</idno>
            <idno type="halBibtex">gaussier:hal-03272295</idno>
            <idno type="halRefHtml">&lt;i&gt;Extremophiles&lt;/i&gt;, 2021, 25, pp.385-392. &lt;a target="_blank" href="https://dx.doi.org/10.1007/s00792-021-01236-x"&gt;&amp;#x27E8;10.1007/s00792-021-01236-x&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Extremophiles, 2021, 25, pp.385-392. &amp;#x27E8;10.1007/s00792-021-01236-x&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3272295-2878195"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="IRD">IRD - Institut de recherche pour le développement</idno>
            <idno type="stamp" n="INSU">INSU - Institut National des Sciences de l'Univers</idno>
            <idno type="stamp" n="UNIV-TLN">Université de Toulon</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
            <idno type="stamp" n="MIO" corresp="OSU-INSTITUT-PYTHEAS">Institut Méditerranéen d'Oceanologie - Mediterranean Institute of Oceanography (MIO)</idno>
            <idno type="stamp" n="OSU-INSTITUT-PYTHEAS">OSU INSTITUT PYTHEAS</idno>
            <idno type="stamp" n="GIP-BE">GIP Bretagne Environnement</idno>
            <idno type="stamp" n="ESPE-AMU_PUBLICATIONS">Publications de l'Ecole Supérieure du Professorat et de l'Education d'Aix Marseille</idno>
            <idno type="stamp" n="MIO-MEB" corresp="MIO">Microbiologie Environnementale Biotechnologie (MEB)</idno>
            <idno type="stamp" n="LISM-AMU">Laboratoire d'ingénierie des systèmes macromoléculaires</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Glutamate optimizes enzymatic activity under high hydrostatic pressure in Desulfovibrio species: effects on the ubiquitous thioredoxin system</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Hélène</forename>
                    <surname>Gaussier</surname>
                  </persName>
                  <email type="md5">8bb9211aa31b1da9fd377a5518d10ef6</email>
                  <email type="domain">univ-amu.fr</email>
                  <idno type="idhal" notation="string">helene-gaussier</idno>
                  <idno type="idhal" notation="numeric">173279</idno>
                  <idno type="halauthorid" notation="string">37259-173279</idno>
                  <affiliation ref="#struct-191652"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M.</forename>
                    <surname>Nouailler</surname>
                  </persName>
                  <email type="md5">fb715ef31650c04ce86f82d231739c3c</email>
                  <email type="domain">univ-amu.fr</email>
                  <idno type="idhal" notation="string">matthieu-nouailler</idno>
                  <idno type="idhal" notation="numeric">744737</idno>
                  <idno type="halauthorid" notation="string">7655-744737</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2061-466X</idno>
                  <idno type="IDREF">https://www.idref.fr/112669565</idno>
                  <affiliation ref="#struct-472"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Edouard</forename>
                    <surname>Champaud</surname>
                  </persName>
                  <idno type="halauthorid">2241133-0</idno>
                  <affiliation ref="#struct-191652"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Edwige</forename>
                    <surname>Garcin</surname>
                  </persName>
                  <idno type="halauthorid">1128245-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sebban</forename>
                    <surname>-Kreuzer</surname>
                  </persName>
                  <email type="md5">1d1ca48aad66f668fe378b163146c200</email>
                  <email type="domain">imm.cnrs.fr</email>
                  <idno type="idhal" notation="string">corinne-sebban-kreuzer</idno>
                  <idno type="idhal" notation="numeric">747092</idno>
                  <idno type="halauthorid" notation="string">2238032-747092</idno>
                  <idno type="IDREF">https://www.idref.fr/169718034</idno>
                  <affiliation ref="#struct-198056"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Olivier</forename>
                    <surname>Bornet</surname>
                  </persName>
                  <email type="md5">b01ede3d0472ab5cec6694c81fb9fe48</email>
                  <email type="domain">imm.cnrs.fr</email>
                  <idno type="idhal" notation="string">olivier-bornet</idno>
                  <idno type="idhal" notation="numeric">1075953</idno>
                  <idno type="halauthorid" notation="string">386571-1075953</idno>
                  <affiliation ref="#struct-186491"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marc</forename>
                    <surname>Garel</surname>
                  </persName>
                  <email type="md5">bb2eb6c5c9c8841d9ac80b2c6fc86178</email>
                  <email type="domain">mio.osupytheas.fr</email>
                  <idno type="idhal" notation="string">marc-garel</idno>
                  <idno type="idhal" notation="numeric">21552</idno>
                  <idno type="halauthorid" notation="string">16260-21552</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4374-5905</idno>
                  <idno type="IDREF">https://www.idref.fr/253133009</idno>
                  <affiliation ref="#struct-191652"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christian</forename>
                    <surname>Tamburini</surname>
                  </persName>
                  <email type="md5">0a937568f7697ae8eae77dfb232661ed</email>
                  <email type="domain">univmed.fr</email>
                  <idno type="idhal" notation="string">christiantamburini</idno>
                  <idno type="idhal" notation="numeric">20223</idno>
                  <idno type="halauthorid" notation="string">26048-20223</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/I-7821-2012</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3752-7423</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.nl/citations?user=LNVxm1UAAAAJ&amp;hl=fr</idno>
                  <idno type="IDREF">https://www.idref.fr/069965625</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/I-7821-2012</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laetitia</forename>
                    <surname>Pieulle</surname>
                  </persName>
                  <email type="md5">bb8ffbdba4e903532aef269c6f2fca9e</email>
                  <email type="domain">imm.cnrs.fr</email>
                  <idno type="idhal" notation="string">laetitia-pieulle</idno>
                  <idno type="idhal" notation="numeric">1021199</idno>
                  <idno type="halauthorid" notation="string">452532-1021199</idno>
                  <affiliation ref="#struct-479"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alain</forename>
                    <surname>Dolla</surname>
                  </persName>
                  <email type="md5">b1f2dea5f3af40edbe62486b4459afa7</email>
                  <email type="domain">mio.osupytheas.fr</email>
                  <idno type="idhal" notation="string">alain-dolla</idno>
                  <idno type="idhal" notation="numeric">20181</idno>
                  <idno type="halauthorid" notation="string">4915-20181</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2930-1336</idno>
                  <idno type="IDREF">https://www.idref.fr/084131128</idno>
                  <affiliation ref="#struct-191652"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nathalie</forename>
                    <surname>Pradel</surname>
                  </persName>
                  <email type="md5">aea9180acb387cc93ce4768ada5bfc81</email>
                  <email type="domain">univ-amu.fr</email>
                  <idno type="idhal" notation="string">nathalie-pradel</idno>
                  <idno type="idhal" notation="numeric">19909</idno>
                  <idno type="halauthorid" notation="string">16272-19909</idno>
                  <affiliation ref="#struct-191652"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">13234</idno>
                <idno type="issn">1431-0651</idno>
                <idno type="eissn">1433-4909</idno>
                <title level="j">Extremophiles</title>
                <imprint>
                  <publisher>Springer Verlag</publisher>
                  <biblScope unit="volume">25</biblScope>
                  <biblScope unit="pp">385–392</biblScope>
                  <date type="datePub">2021</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1007/s00792-021-01236-x</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">hydrostatic pressure</term>
                <term xml:lang="en">co-solute</term>
                <term xml:lang="en">glutamate</term>
                <term xml:lang="en">thioredoxin</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.bbm.bc">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]</classCode>
              <classCode scheme="halDomain" n="sdu.ocean">Sciences of the Universe [physics]/Ocean, Atmosphere</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>In piezophilic microorganisms, enzymes are optimized to perform under high hydrostatic pressure. The two major reported mechanisms responsible for such adaptation in bacterial species are changes in amino acids in the protein structure, favoring their activity and stability under high-pressure conditions, and the possible accumulation of micromolecular co-solutes in the cytoplasm. Recently, the accumulation of glutamate in the cytoplasm of piezophilic Desulfovibrio species has been reported under high pressure growth conditions. In this study, analysis of the effect of glutamate on the enzymatic activity of the thioredoxin reductase/thioredoxin enzymatic complex of either a piezosensitive or a piezophilic microorganism confirms its role as a protective co-solute. Analysis of the thioredoxin structures suggests an adaptation both to the presence of glutamate and to high hydrostatic pressure in the enzyme from the piezophilic strain. Indeed, the presence of large surface pockets could counterbalance the overall compression that occurs at high hydrostatic pressure to maintain enzymatic activity. A lower isoelectric point and a greater dipolar moment than that of thioredoxin from the piezosensitive strain would allow the protein from the piezophilic strain to compensate for the presence of the charged amino acid glutamate to interact with its partner.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-191652" status="VALID">
          <idno type="IdRef">167663925</idno>
          <idno type="ISNI">0000000417586271</idno>
          <idno type="RNSR">201220349W</idno>
          <idno type="ROR">https://ror.org/05258q350</idno>
          <idno type="Wikidata">Q3152368</idno>
          <orgName>Institut méditerranéen d'océanologie</orgName>
          <orgName type="acronym">MIO</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>M.I.O. Institut Méditerranéen d'Océanologie Bâtiment Méditerranée163 Avenue de Luminy13288 Marseille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.mio.univ-amu.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR_D235" active="#struct-67872" type="direct"/>
            <relation name="UM110" active="#struct-198056" type="direct"/>
            <relation name="UMR7294" active="#struct-300045" type="direct"/>
            <relation name="UMR7294" active="#struct-303091" type="direct"/>
            <relation name="UMR7294" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-472" status="VALID">
          <idno type="IdRef">150500378</idno>
          <idno type="RNSR">201220358F</idno>
          <idno type="ROR">02hwc1z56</idno>
          <orgName>Laboratoire d'ingénierie des systèmes macromoléculaires</orgName>
          <orgName type="acronym">LISM</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Batiment IBSM 31 Chemin Joseph Aiguier 13402 MARSEILLE CEDEX 20</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://lism.cnrs-mrs.fr</ref>
          </desc>
          <listRelation>
            <relation name="UMR7255" active="#struct-198056" type="direct"/>
            <relation name="UMR7255" active="#struct-303623" type="direct"/>
            <relation name="UMR7255 / UPR9027" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-198056" status="VALID">
          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <idno type="ROR">https://ror.org/035xkbk20</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-186491" status="VALID">
          <idno type="RNSR">201220484T</idno>
          <idno type="ROR">012t91r40</idno>
          <orgName>Institut de Microbiologie de la Méditerranée</orgName>
          <orgName type="acronym">IMM</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>31, chemin Joseph Aiguier 13402 Marseille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.imm.cnrs.fr/</ref>
          </desc>
          <listRelation>
            <relation name="FR3479" active="#struct-198056" type="direct"/>
            <relation name="UAR2044 / FR3479" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-479" status="VALID">
          <idno type="IdRef">150008651</idno>
          <idno type="RNSR">201220357E</idno>
          <idno type="ROR">057zme681</idno>
          <orgName>Laboratoire de chimie bactérienne</orgName>
          <orgName type="acronym">LCB</orgName>
          <date type="start">2012</date>
          <desc>
            <address>
              <addrLine>31 Chemin Joseph Aiguier 13402 MARSEILLE CEDEX 20</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://lcb.cnrs-mrs.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR7283" active="#struct-198056" type="direct"/>
            <relation name="UMR7283" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-67872" status="VALID">
          <idno type="IdRef">050165224</idno>
          <idno type="ROR">https://ror.org/05q3vnk25</idno>
          <orgName>Institut de Recherche pour le Développement</orgName>
          <orgName type="acronym">IRD</orgName>
          <desc>
            <address>
              <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ird.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300045" status="VALID">
          <idno type="IdRef">029349265</idno>
          <idno type="ISNI">0000 0001 2154 1736</idno>
          <idno type="ROR">https://ror.org/04kdfz702</idno>
          <idno type="Wikidata">Q3152437</idno>
          <orgName>Institut national des sciences de l'Univers</orgName>
          <orgName type="acronym">INSU - CNRS</orgName>
          <date type="start">2007-04-19</date>
          <desc>
            <address>
              <addrLine>INSU-CNRS3 rue Michel-Ange, 75794 Paris Cedex 16</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.insu.cnrs.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303091" status="VALID">
          <idno type="IdRef">031122337</idno>
          <idno type="ROR">https://ror.org/02m9kbe37</idno>
          <orgName>Université de Toulon</orgName>
          <orgName type="acronym">UTLN</orgName>
          <desc>
            <address>
              <addrLine>Avenue de l'Université - BP 20132 - 83957 La Garde Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tln.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>