New Synthesis of sn-1,2-and sn-2,3-O-Diacylglycerols ؊ Application to the Synthesis of Enantiopure Phosphonates Analogous to Triglycerides: A New Class of Inhibitors of Lipases - Archive ouverte HAL Access content directly
Journal Articles European Journal of Organic Chemistry Year : 1999

New Synthesis of sn-1,2-and sn-2,3-O-Diacylglycerols ؊ Application to the Synthesis of Enantiopure Phosphonates Analogous to Triglycerides: A New Class of Inhibitors of Lipases

Abstract

Phosphonate compounds mimic the first transition state from a C-4 chiral synthon, 3-buten-1,2-diol-and treated with n-pentylphosphonic dichloride and p-nitrophenol to occurring during enzymatic carboxyester hydrolysis of natural substrates by forming a covalent bond with the afford the corresponding diastereomeric phosphonates, which were acylglycerol analogs. Subsequent separation of catalytic serine. However, until now the organophosphorus compounds used in the inhibition studies more or less each of the phosphonate diastereomers A/B or ent-A/ent-B, performed by HPLC, led to four enantiopure stereoisomers resembled a natural triglyceride substrate. In order to elucidate the interfacial activation and the mechanism of that will be investigated as inhibitors of Human Pancreatic Lipase (HPL) and Human Gastric Lipase (HGL) using the action of lipases, specific inhibitors need to be prepared. To achieve this goal, enantiomerically pure sn-1,2-and sn-2,3-monomolecular film technique.
No file

Dates and versions

hal-03272194 , version 1 (06-07-2021)

Identifiers

  • HAL Id : hal-03272194 , version 1

Cite

Frank Marguet, Jean-François Cavalier, Robert Verger, Gérard Buono. New Synthesis of sn-1,2-and sn-2,3-O-Diacylglycerols ؊ Application to the Synthesis of Enantiopure Phosphonates Analogous to Triglycerides: A New Class of Inhibitors of Lipases. European Journal of Organic Chemistry, 1999. ⟨hal-03272194⟩
20 View
2 Download

Share

Gmail Mastodon Facebook X LinkedIn More