<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03268812</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-16T11:34:49+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Suspect screening and targeted analyses: Two complementary approaches to characterize human exposure to pesticides</title>
            <author role="crp">
              <persName>
                <forename type="first">Nathalie</forename>
                <surname>Bonvallot</surname>
              </persName>
              <email type="md5">3061fbe57f873a55cf7eca1f157f1444</email>
              <email type="domain">ehesp.fr</email>
              <idno type="idhal" notation="string">nathalie-bonvallot</idno>
              <idno type="idhal" notation="numeric">17548</idno>
              <idno type="halauthorid" notation="string">19065-17548</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/J-9378-2015</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8070-6008</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=4jGV3MQAAAAJ&amp;hl=fr&amp;oi=ao</idno>
              <idno type="IDREF">https://www.idref.fr/074002740</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/J-9378-2015</idno>
              <affiliation ref="#struct-182194"/>
              <affiliation ref="#struct-301986"/>
              <affiliation ref="#struct-232148"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Emilien L.</forename>
                <surname>Jamin</surname>
              </persName>
              <email type="md5">cbaa78565910b27805fb27de2dd9c7ed</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">ejamin</idno>
              <idno type="idhal" notation="numeric">751799</idno>
              <idno type="halauthorid" notation="string">1199760-751799</idno>
              <idno type="IDREF">https://www.idref.fr/125987889</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4568-9177</idno>
              <affiliation ref="#struct-439073"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">L.</forename>
                <surname>Regnaut</surname>
              </persName>
              <idno type="halauthorid">2235522-0</idno>
              <affiliation ref="#struct-182194"/>
              <affiliation ref="#struct-301986"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-François</forename>
                <surname>Martin</surname>
              </persName>
              <idno type="halauthorid">36934-0</idno>
              <orgName ref="#struct-474617"/>
              <affiliation ref="#struct-439073"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">C.</forename>
                <surname>Chevrier</surname>
              </persName>
              <email type="md5">476b2a93e44ec3136aa313af8aa5d43d</email>
              <email type="domain">rennes.inserm.fr</email>
              <idno type="idhal" notation="numeric">1157015</idno>
              <idno type="halauthorid" notation="string">2235523-1157015</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3101-8222</idno>
              <idno type="IDREF">https://www.idref.fr/095119175</idno>
              <idno type="VIAF">https://viaf.org/viaf/208971437</idno>
              <idno type="ISNI">http://isni.org/isni/0000000140831798</idno>
              <affiliation ref="#struct-182194"/>
              <affiliation ref="#struct-301986"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fabien</forename>
                <surname>Mercier</surname>
              </persName>
              <email type="md5">9869e19b0abf2a224118927adb7b103b</email>
              <email type="domain">ehesp.fr</email>
              <idno type="idhal" notation="string">fabien-mercier</idno>
              <idno type="idhal" notation="numeric">17142</idno>
              <idno type="halauthorid" notation="string">19392-17142</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/K-7371-2015</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9523-4277</idno>
              <idno type="IDREF">https://www.idref.fr/166312347</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/K-7371-2015</idno>
              <affiliation ref="#struct-182194"/>
              <affiliation ref="#struct-301986"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">S.</forename>
                <surname>Cordier</surname>
              </persName>
              <email type="md5">5137a8062f6d90cffdf9699e920079b7</email>
              <email type="domain">rennes.inserm.fr</email>
              <idno type="idhal" notation="numeric">879040</idno>
              <idno type="halauthorid" notation="string">1839272-879040</idno>
              <idno type="IDREF">https://www.idref.fr/074595296</idno>
              <idno type="VIAF">https://viaf.org/viaf/190607104</idno>
              <idno type="ISNI">http://isni.org/isni/0000000430964054</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2349-2277</idno>
              <affiliation ref="#struct-182194"/>
              <affiliation ref="#struct-301986"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Pierre</forename>
                <surname>Cravedi</surname>
              </persName>
              <email type="md5">21fa9b4fb82c99ba992772933c2b194d</email>
              <email type="domain">free.fr</email>
              <idno type="idhal" notation="numeric">808374</idno>
              <idno type="halauthorid" notation="string">2263003-808374</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9247-7567</idno>
              <idno type="IDREF">https://www.idref.fr/059833092</idno>
              <idno type="VIAF">https://viaf.org/viaf/209997558</idno>
              <idno type="ISNI">http://isni.org/isni/0000000431974094</idno>
              <affiliation ref="#struct-1002184"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laurent</forename>
                <surname>Debrauwer</surname>
              </persName>
              <email type="md5">ce3a74b02c16c6fcf8bbcd5d8c321296</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">laurent-debrauwer</idno>
              <idno type="idhal" notation="numeric">1106714</idno>
              <idno type="halauthorid" notation="string">500257-1106714</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3600-0902</idno>
              <idno type="IDREF">https://www.idref.fr/126035288</idno>
              <orgName ref="#struct-577435"/>
              <affiliation ref="#struct-439073"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Barbara</forename>
                <surname>Le Bot</surname>
              </persName>
              <email type="md5">7bd9c7882be0af24dd959de0a68b0a7e</email>
              <email type="domain">ehesp.fr</email>
              <idno type="idhal" notation="string">barbara-le-bot</idno>
              <idno type="idhal" notation="numeric">174880</idno>
              <idno type="halauthorid" notation="string">19452-174880</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=ioW78woAAAAJ&amp;hl=fr&amp;oi=ao</idno>
              <idno type="IDREF">https://www.idref.fr/16160367X</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9463-0924</idno>
              <affiliation ref="#struct-182194"/>
              <affiliation ref="#struct-301986"/>
              <affiliation ref="#struct-10127"/>
              <affiliation ref="#struct-232148"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Laurent</forename>
                <surname>Jonchère</surname>
              </persName>
              <email type="md5">dc1f1e9bdb3dc2065f8bf1bfd5663118</email>
              <email type="domain">univ-rennes.fr</email>
            </editor>
            <funder ref="#projanr-50454"/>
            <funder>This work was sponsored by the French PNRPE program (Programme National de Recherche sur les Pertubateurs Endocriniens) [13-MRES-PNRPE-7-CVS-049, 2013]. All suspect screening experiments were performed on the instruments of the MetaToul-AXIOM platform, partner of the national infrastructure of metabolomics and fluxomics: MetaboHUB [MetaboHUB-ANR-11-INBS-0010, 2011].</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2021-06-30 12:24:16</date>
              <date type="whenModified">2026-03-18 14:22:02</date>
              <date type="whenReleased">2021-07-06 08:01:37</date>
              <date type="whenProduced">2021-09</date>
              <date type="whenEndEmbargoed">2021-11-04</date>
              <ref type="file" target="https://hal.science/hal-03268812v1/document">
                <date notBefore="2021-11-04"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-03268812v1/file/Bonvallot%20et%20al.%20-%202021%20-%20Suspect%20screening%20and%20targeted%20analyses%20two%20compl.pdf" id="file-3274651-2877306">
                <date notBefore="2021-11-04"/>
              </ref>
              <ref type="annex" n="0" target="https://hal.science/hal-03268812v1/file/Bonvallot_ScienceDirect_files_30Jun2021_10-20-39.960.zip" id="file-3274651-2877307">
                <date notBefore="2021-11-04"/>
              </ref>
              <fs>
                <f name="inra_etatDocument_local" notation="numeric">
                  <numeric>0</numeric>
                </f>
                <f name="inra_etatDocument_local" notation="string" n="0">
                  <string>inra_etatDocument_local_0</string>
                </f>
                <f name="inra_publicVise_local" notation="string" n="SC">
                  <string>inra_publicVise_local_SC</string>
                </f>
              </fs>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="113861">
                <persName>
                  <forename>Laurent</forename>
                  <surname>Jonchère</surname>
                </persName>
                <email type="md5">dc1f1e9bdb3dc2065f8bf1bfd5663118</email>
                <email type="domain">univ-rennes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03268812</idno>
            <idno type="halUri">https://hal.science/hal-03268812</idno>
            <idno type="halBibtex">bonvallot:hal-03268812</idno>
            <idno type="halRefHtml">&lt;i&gt;Science of the Total Environment&lt;/i&gt;, 2021, 786, pp.147499. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.scitotenv.2021.147499"&gt;&amp;#x27E8;10.1016/j.scitotenv.2021.147499&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Science of the Total Environment, 2021, 786, pp.147499. &amp;#x27E8;10.1016/j.scitotenv.2021.147499&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3274651-2877306"/><ref corresp="#file-3274651-2877307"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="SDE">Sciences De l'Environnement</idno>
            <idno type="stamp" n="UNIV-TLSE3">Université de Toulouse</idno>
            <idno type="stamp" n="UNIV-RENNES1">Université de Rennes 1</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-ANGERS">Université d'Angers</idno>
            <idno type="stamp" n="SANTE_PUB_INSERM" corresp="INSERM">Santé Publique à l'Inserm</idno>
            <idno type="stamp" n="IFR140">SFR Biosit - Biologie et Santé CNRS UMS 3480</idno>
            <idno type="stamp" n="GIP-BE">GIP Bretagne Environnement</idno>
            <idno type="stamp" n="IRSET">Institut de Recherche en Santé, Environnement et Travail</idno>
            <idno type="stamp" n="STATS-UR1">Statistiques-HAL-UR1</idno>
            <idno type="stamp" n="IRSET-TREC" corresp="IRSET">TRANSCRIPTION, ENVIRONMENT and CANCER (TREC)</idno>
            <idno type="stamp" n="IRSET-NEED" corresp="IRSET">NEUROENDOCRINE EFFECTS OF ENDOCRINE DISRUPTORS</idno>
            <idno type="stamp" n="IRSET-TNGC" corresp="IRSET">Recherches épidémiologiques sur l'environnement, la reproduction et le développement</idno>
            <idno type="stamp" n="IRSET-LERES" corresp="IRSET"> Laboratoire d’Etude et de Recherche en Environnement et santé (LERES)</idno>
            <idno type="stamp" n="UR1-UFR-SVE">UFR SVE Sciences de la vie et de l'environnement</idno>
            <idno type="stamp" n="UR1-HAL">Publications labos UR1 dans HAL-Rennes 1</idno>
            <idno type="stamp" n="EHESP">École des hautes études en santé publique</idno>
            <idno type="stamp" n="UR1-SDV">UR1 - publications SDV</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="IRSET-9" corresp="IRSET">CHEVRIER-GARLANTÉZEC - Evaluation des expositions et recherche épidémiologique sur l'environnement, la reproduction et le développement (3ERD)</idno>
            <idno type="stamp" n="IRSET-EHESP" corresp="EHESP">EHESP-Irset</idno>
            <idno type="stamp" n="DSETGS" corresp="EHESP">EHESP-DSETGS</idno>
            <idno type="stamp" n="TEST-UR-CSS">TEST Université de Rennes CSS</idno>
            <idno type="stamp" n="UNIV-RENNES">Université de Rennes</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="UR1-BIO-SA">Pôle UnivRennes - Biologie-Santé</idno>
            <idno type="stamp" n="TOXALIM" corresp="INRAE">ToxAlim</idno>
            <idno type="stamp" n="INRAEOCCITANIETOULOUSE" corresp="INRAE">INRAE Occitanie Toulouse</idno>
            <idno type="stamp" n="TOXALIM-METATOUL-AXIOM" corresp="TOXALIM">Analyse de Xénobiotiques, Identification, Métabolisme</idno>
            <idno type="stamp" n="TOULOUSE-INP">Toulouse - INP</idno>
            <idno type="stamp" n="UNIV-UT3">Université Toulouse 3</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="TEST3-HALCNRS">TEST3-HALCNRS</idno>
            <idno type="stamp" n="METABOHUB">Metabohub : Infrastructure nationale en métabolomique et fluxomique </idno>
            <idno type="stamp" n="ALIMH">Département Alimentation Humaine</idno>
            <idno type="stamp" n="ENVT">École Nationale Vétérinaire de Toulouse </idno>
            <idno type="stamp" n="EIPURPAN">EIPURPAN</idno>
            <idno type="stamp" n="DPT-SANTE-ANIMALE">Département Santé Animale</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Suspect screening and targeted analyses: Two complementary approaches to characterize human exposure to pesticides</title>
                <author role="crp">
                  <persName>
                    <forename type="first">Nathalie</forename>
                    <surname>Bonvallot</surname>
                  </persName>
                  <email type="md5">3061fbe57f873a55cf7eca1f157f1444</email>
                  <email type="domain">ehesp.fr</email>
                  <idno type="idhal" notation="string">nathalie-bonvallot</idno>
                  <idno type="idhal" notation="numeric">17548</idno>
                  <idno type="halauthorid" notation="string">19065-17548</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/J-9378-2015</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8070-6008</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=4jGV3MQAAAAJ&amp;hl=fr&amp;oi=ao</idno>
                  <idno type="IDREF">https://www.idref.fr/074002740</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/J-9378-2015</idno>
                  <affiliation ref="#struct-182194"/>
                  <affiliation ref="#struct-301986"/>
                  <affiliation ref="#struct-232148"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Emilien L.</forename>
                    <surname>Jamin</surname>
                  </persName>
                  <email type="md5">cbaa78565910b27805fb27de2dd9c7ed</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">ejamin</idno>
                  <idno type="idhal" notation="numeric">751799</idno>
                  <idno type="halauthorid" notation="string">1199760-751799</idno>
                  <idno type="IDREF">https://www.idref.fr/125987889</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4568-9177</idno>
                  <affiliation ref="#struct-439073"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">L.</forename>
                    <surname>Regnaut</surname>
                  </persName>
                  <idno type="halauthorid">2235522-0</idno>
                  <affiliation ref="#struct-182194"/>
                  <affiliation ref="#struct-301986"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-François</forename>
                    <surname>Martin</surname>
                  </persName>
                  <idno type="halauthorid">36934-0</idno>
                  <orgName ref="#struct-474617"/>
                  <affiliation ref="#struct-439073"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">C.</forename>
                    <surname>Chevrier</surname>
                  </persName>
                  <email type="md5">476b2a93e44ec3136aa313af8aa5d43d</email>
                  <email type="domain">rennes.inserm.fr</email>
                  <idno type="idhal" notation="numeric">1157015</idno>
                  <idno type="halauthorid" notation="string">2235523-1157015</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3101-8222</idno>
                  <idno type="IDREF">https://www.idref.fr/095119175</idno>
                  <idno type="VIAF">https://viaf.org/viaf/208971437</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000140831798</idno>
                  <affiliation ref="#struct-182194"/>
                  <affiliation ref="#struct-301986"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fabien</forename>
                    <surname>Mercier</surname>
                  </persName>
                  <email type="md5">9869e19b0abf2a224118927adb7b103b</email>
                  <email type="domain">ehesp.fr</email>
                  <idno type="idhal" notation="string">fabien-mercier</idno>
                  <idno type="idhal" notation="numeric">17142</idno>
                  <idno type="halauthorid" notation="string">19392-17142</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/K-7371-2015</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9523-4277</idno>
                  <idno type="IDREF">https://www.idref.fr/166312347</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/K-7371-2015</idno>
                  <affiliation ref="#struct-182194"/>
                  <affiliation ref="#struct-301986"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">S.</forename>
                    <surname>Cordier</surname>
                  </persName>
                  <email type="md5">5137a8062f6d90cffdf9699e920079b7</email>
                  <email type="domain">rennes.inserm.fr</email>
                  <idno type="idhal" notation="numeric">879040</idno>
                  <idno type="halauthorid" notation="string">1839272-879040</idno>
                  <idno type="IDREF">https://www.idref.fr/074595296</idno>
                  <idno type="VIAF">https://viaf.org/viaf/190607104</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000430964054</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2349-2277</idno>
                  <affiliation ref="#struct-182194"/>
                  <affiliation ref="#struct-301986"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Pierre</forename>
                    <surname>Cravedi</surname>
                  </persName>
                  <email type="md5">21fa9b4fb82c99ba992772933c2b194d</email>
                  <email type="domain">free.fr</email>
                  <idno type="idhal" notation="numeric">808374</idno>
                  <idno type="halauthorid" notation="string">2263003-808374</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9247-7567</idno>
                  <idno type="IDREF">https://www.idref.fr/059833092</idno>
                  <idno type="VIAF">https://viaf.org/viaf/209997558</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000431974094</idno>
                  <affiliation ref="#struct-1002184"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laurent</forename>
                    <surname>Debrauwer</surname>
                  </persName>
                  <email type="md5">ce3a74b02c16c6fcf8bbcd5d8c321296</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">laurent-debrauwer</idno>
                  <idno type="idhal" notation="numeric">1106714</idno>
                  <idno type="halauthorid" notation="string">500257-1106714</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3600-0902</idno>
                  <idno type="IDREF">https://www.idref.fr/126035288</idno>
                  <orgName ref="#struct-577435"/>
                  <affiliation ref="#struct-439073"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Barbara</forename>
                    <surname>Le Bot</surname>
                  </persName>
                  <email type="md5">7bd9c7882be0af24dd959de0a68b0a7e</email>
                  <email type="domain">ehesp.fr</email>
                  <idno type="idhal" notation="string">barbara-le-bot</idno>
                  <idno type="idhal" notation="numeric">174880</idno>
                  <idno type="halauthorid" notation="string">19452-174880</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=ioW78woAAAAJ&amp;hl=fr&amp;oi=ao</idno>
                  <idno type="IDREF">https://www.idref.fr/16160367X</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9463-0924</idno>
                  <affiliation ref="#struct-182194"/>
                  <affiliation ref="#struct-301986"/>
                  <affiliation ref="#struct-10127"/>
                  <affiliation ref="#struct-232148"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">18830</idno>
                <idno type="issn">0048-9697</idno>
                <idno type="eissn">1879-1026</idno>
                <title level="j">Science of the Total Environment</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">786</biblScope>
                  <biblScope unit="pp">147499</biblScope>
                  <date type="datePub">2021-09</date>
                  <date type="dateEpub">2021-05-04</date>
                </imprint>
              </monogr>
              <idno type="bibcode">2021ScTEn.786n7499B</idno>
              <idno type="doi">10.1016/j.scitotenv.2021.147499</idno>
              <idno type="wos">000660298100012</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Mass spectrometry</term>
                <term xml:lang="en">Biomarkers</term>
                <term xml:lang="en">Biocides</term>
                <term xml:lang="en">Mixtures</term>
                <term xml:lang="en">Plant protection products</term>
              </keywords>
              <classCode scheme="halDomain" n="sde">Environmental Sciences</classCode>
              <classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Characterizing human exposure to pesticides is challenging because their metabolites have a broad diversity of chemical structures. We aimed to study the interest of associating suspect screening and targeted analysis to identify multiple pesticide exposure of pregnant women. Approximately 300 urinary samples collected during early pregnancy (France) were analyzed by UHPLC/HRMS using both a suspect screening approach and targeted multiresidue analysis. Sixty-eight pesticides were selected according to available data on agricultural practices and analytical feasibility and 435 known or putative metabolites were added based on the literature. Compounds detected using the two approaches were compared and the place of residence was studied as a determinant of exposure for illustrative purposes. Suspect screening resulted in the characterization of 28 pesticide metabolites, corresponding to three fungicides (azoxystrobin, fenpropimorph, and procymidone), three herbicides (an arylphenoxypropionic acid derivative, chlorpropham, and phenmedipham), and one insecticide (carbofuran). The targeted approach led to the identification of pyrethroids, organophosphorus, fluazifop-P-butyl, and chlorpyrifos in &amp;gt;60% of samples and prochloraz, bromoxynil, diazinon, and procymidone in 10 to 50%. Both urban and rural areas were identified as being determinants of exposure, depending on the active substance. This combined strategy better characterizes pesticide mixtures. Suspect screening allows the detection of metabolites of pesticides that are rarely studied and not measured in biomonitoring studies, mainly because it allows the detection of conjugated phase II metabolites (azoxystrobin and fenpropimorph). The targeted approach complements it with the detection of highly polar and low molecular-weight metabolites, the confirmation of the parent compound, and the quantification of compounds for which analytical standards are commercially available or may be synthesized (organophosphorous, pyrethroids, and fluazifop-P-butyl). In addition, we detected several metabolites that have never been described in humans (fenpropimorph and azoxystrobin), which deserve to be candidates in the selection of markers of exposure.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-182194" status="VALID">
          <idno type="IdRef">177984775</idno>
          <idno type="RNSR">201722263E</idno>
          <idno type="ROR">https://ror.org/01p178v10</idno>
          <idno type="Wikidata">Q30261433</idno>
          <orgName>Institut de recherche en santé, environnement et travail</orgName>
          <orgName type="acronym">Irset</orgName>
          <date type="start">2009-01-01</date>
          <desc>
            <address>
              <addrLine>263 avenue Général Leclerc 35042 Rennes Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.irset.org</ref>
          </desc>
          <listRelation>
            <relation active="#struct-74911" type="direct"/>
            <relation active="#struct-105160" type="direct"/>
            <relation active="#struct-301986" type="direct"/>
            <relation name="U1085" active="#struct-303623" type="direct"/>
            <relation active="#struct-453207" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301986" status="VALID">
          <idno type="IdRef">161356915</idno>
          <idno type="ISNI">0000 0001 1943 5037</idno>
          <idno type="ROR">https://ror.org/01sc83v92</idno>
          <orgName>École des Hautes Études en Santé Publique</orgName>
          <orgName type="acronym">EHESP</orgName>
          <date type="start">2008-01-01</date>
          <desc>
            <address>
              <addrLine>15, avenue du Pr. Léon Bernard - 35043 Rennes Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ehesp.fr/</ref>
          </desc>
        </org>
        <org type="department" xml:id="struct-232148" status="OLD">
          <orgName>Département Santé Environnement Travail et Génie Sanitaire</orgName>
          <orgName type="acronym">DSETGS</orgName>
          <date type="start">2008-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>15, avenue du Pr. Léon Bernard - 35043 Rennes Cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-301986" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-439073" status="OLD">
          <orgName>Metatoul AXIOM</orgName>
          <orgName type="acronym">E20</orgName>
          <date type="start">2020-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>Analyse de Xénobiotiques, Identification, Métabolisme, Plateforme de Métabolomique et de Chimie Analytique en Toxicologie23 ch. Capelles 31076 TOULOUSE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www6.toulouse.inrae.fr/toxalim/Plateformes-Technologiques/E20-Metatoul-AXIOM</ref>
          </desc>
          <listRelation>
            <relation active="#struct-552749" type="direct"/>
            <relation active="#struct-414014" type="indirect"/>
            <relation active="#struct-1002361" type="indirect"/>
            <relation active="#struct-217752" type="indirect"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-300421" type="indirect"/>
            <relation active="#struct-448187" type="indirect"/>
            <relation active="#struct-303623" type="indirect"/>
            <relation name="UAR2039" active="#struct-441569" type="indirect"/>
            <relation active="#struct-577435" type="indirect"/>
            <relation active="#struct-1002184" type="direct"/>
            <relation active="#struct-460848" type="indirect"/>
            <relation name="UMR1331" active="#struct-577435" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1002184" status="OLD">
          <idno type="IdRef">168079968</idno>
          <idno type="RNSR">201119649P</idno>
          <orgName>ToxAlim</orgName>
          <orgName type="acronym">ToxAlim</orgName>
          <date type="start">2020-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>23 ch. Capelles 31076 TOULOUSE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www4.toulouse.inra.fr/toxalim</ref>
          </desc>
          <listRelation>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-300421" type="direct"/>
            <relation active="#struct-448187" type="direct"/>
            <relation active="#struct-460848" type="direct"/>
            <relation name="UMR1331" active="#struct-577435" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-10127" status="VALID">
          <orgName>Laboratoire d'étude et de recherche en environnement et santé</orgName>
          <orgName type="acronym">LERES</orgName>
          <date type="start">1988-01-01</date>
          <desc>
            <address>
              <addrLine>EHESP, 15 Avenue du Professeur Léon-Bernard - 35043 Rennes cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://leres.ehesp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301986" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-74911" status="VALID">
          <idno type="IdRef">026402920</idno>
          <idno type="ISNI">0000000122483363</idno>
          <idno type="ROR">https://ror.org/04yrqp957</idno>
          <orgName>Université d'Angers</orgName>
          <orgName type="acronym">UA</orgName>
          <date type="start">1971-10-25</date>
          <desc>
            <address>
              <addrLine>Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-angers.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-105160" status="VALID">
          <idno type="IdRef">26693823X</idno>
          <idno type="ROR">https://ror.org/015m7wh34</idno>
          <orgName>Université de Rennes</orgName>
          <orgName type="acronym">UR</orgName>
          <desc>
            <address>
              <addrLine>Campus de Beaulieu, 263 avenue Général Leclerc, CS 74205, 35042 RENNES CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-rennes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-453207" status="VALID">
          <idno type="IdRef">200295462</idno>
          <idno type="RNSR">201220717W</idno>
          <idno type="ROR">https://ror.org/05cx7ek10</idno>
          <orgName>Structure Fédérative de Recherche en Biologie et Santé de Rennes</orgName>
          <orgName type="acronym">Biosit : Biologie - Santé - Innovation Technologique</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Rennes - Campus Santé Villejean -  2, avenue Professeur Léon Bernard 35043 Rennes cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://biosit.univ-rennes.fr/</ref>
          </desc>
        </org>
        <org type="department" xml:id="struct-552749" status="OLD">
          <orgName>MetaboHUB-MetaToul</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>Regroupement de 4 plateformes technologiques et d’expertises Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www6.toulouse.inrae.fr/metatoul/Presentation</ref>
          </desc>
          <listRelation>
            <relation active="#struct-414014" type="direct"/>
            <relation active="#struct-1002361" type="direct"/>
            <relation active="#struct-217752" type="indirect"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-300421" type="indirect"/>
            <relation active="#struct-448187" type="indirect"/>
            <relation active="#struct-303623" type="indirect"/>
            <relation name="UAR2039" active="#struct-441569" type="indirect"/>
            <relation active="#struct-577435" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-414014" status="VALID">
          <idno type="ROR">https://ror.org/039gscz82</idno>
          <idno type="Wikidata">Q107518509</idno>
          <orgName>MetaboHUB</orgName>
          <date type="start">2013-01-01</date>
          <desc>
            <address>
              <addrLine>135 Avenue de Rangueil,31400 Toulouse, FRANCE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.metabohub.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1002361" status="OLD">
          <idno type="RNSR">202424518A</idno>
          <orgName>Génopole Toulouse Midi-Pyrénées [Auzeville]</orgName>
          <orgName type="acronym">GENOTOUL</orgName>
          <date type="start">2020-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>Chemin de Borde-Rouge Auzeville</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-300421" type="direct"/>
            <relation active="#struct-448187" type="direct"/>
            <relation active="#struct-303623" type="direct"/>
            <relation name="UAR2039" active="#struct-441569" type="direct"/>
            <relation active="#struct-577435" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-217752" status="OLD">
          <idno type="IdRef">026404672</idno>
          <idno type="ISNI">0000000121617331</idno>
          <idno type="ROR">https://ror.org/02v6kpv12</idno>
          <idno type="Wikidata">Q1273188</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-300421" status="VALID">
          <idno type="ROR">https://ror.org/03m3gzv89</idno>
          <orgName>École nationale vétérinaire de Toulouse</orgName>
          <orgName type="acronym">ENVT</orgName>
          <desc>
            <address>
              <addrLine>23 chemin des Capelles - 31076 Toulouse Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://envt.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-448187" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-448187" status="VALID">
          <idno type="IdRef">026388820</idno>
          <idno type="ISNI">0000000121766169</idno>
          <idno type="ROR">https://ror.org/033p9g875</idno>
          <orgName>Institut National Polytechnique (Toulouse)</orgName>
          <orgName type="acronym">Toulouse INP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.inp-toulouse.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-577435" status="VALID">
          <idno type="ROR">https://ror.org/003vg9w96</idno>
          <orgName>Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement</orgName>
          <orgName type="acronym">INRAE</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-460848" status="OLD">
          <idno type="ROR">https://ror.org/008bwpw24</idno>
          <orgName>Ecole d'Ingénieurs de Purpan</orgName>
          <orgName type="acronym">INP - PURPAN</orgName>
          <date type="start">2006-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.purpan.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-448187" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
          </listRelation>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-50454" status="VALID">
          <idno type="anr">ANR-11-INBS-0010</idno>
          <orgName>METABOHUB</orgName>
          <desc>Développement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovation</desc>
          <date type="start">2011</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>