Au(I)-Catalyzed Pictet-Spengler Reactions all Around the Indole Ring - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Organic Chemistry Année : 2021

Au(I)-Catalyzed Pictet-Spengler Reactions all Around the Indole Ring

Résumé

Au(I) complexes catalyze iso-Pictet-Spengler reactions. Ethylamine or methylamine chains were introduced at C2, C4 or at the nitrogen atom of the indole ring, and the corresponding substrates were reacted in the presence of aldehydes and catalytic amounts of Au(I) complexes, leading to a variety of polycyclic scaffolds. Selectivity could be achieved in the course of a double iso-Pictet-Spengler reaction involving two successive aldehydes, leading to highly complex molecules.
Fichier principal
Vignette du fichier
isoPS Au.pdf (1.73 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03267801 , version 1 (22-06-2021)

Identifiants

Citer

Pierre Milcendeau, Zhenhao Zhang, Nicolas Glinsky-Olivier, Elsa van Elslande, Xavier Guinchard. Au(I)-Catalyzed Pictet-Spengler Reactions all Around the Indole Ring. Journal of Organic Chemistry, 2021, 86 (9), pp.6406-6422. ⟨10.1021/acs.joc.1c00270⟩. ⟨hal-03267801⟩
49 Consultations
158 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More