Biotransformation of guttiferones, Symphonia globulifera metabolites, by Bipolaris cactivora , an endophytic fungus isolated from its leaves - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Organic & Biomolecular Chemistry Année : 2021

Biotransformation of guttiferones, Symphonia globulifera metabolites, by Bipolaris cactivora , an endophytic fungus isolated from its leaves

Résumé

The search for active microorganisms for the biotransformation of guttiferone A (1) and C (6) has been successfully undertaken from a collection of endophytic fungi of Symphonia globulifera. Of the twenty-five isolates obtained from the leaves, three are active and have been identified as Bipolaris cactivora. The products obtained are the result of xanthone cyclisation with the formation of two regioisomers among four possible and corresponding to 1,16-oxy-guttiferone and 3,16-oxy-guttiferone. The biotransformation conditions were studied. Interestingly, both oxy-guttiferones A are present in the plant, and the ratio of 3,16-oxy-guttiferone to 1,16-oxy-guttiferone is 4 : 1, very close to that observed by biotransformation (3.8 : 1). These results are consistent with the involvement of endophytes in their formation pathway from guttiferone A, in planta. Finally, biotransformation made it possible to obtain and describe for the first time oxy-guttiferones C.
Fichier principal
Vignette du fichier
Menelle-2021-Biotransformation of guttiferones.pdf (308.43 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03262416 , version 1 (26-11-2021)

Identifiants

Citer

Pauline Menelle, Jérôme Quintin, Kevin Cottet, Yann Fromentin, Joëlle Dupont, et al.. Biotransformation of guttiferones, Symphonia globulifera metabolites, by Bipolaris cactivora , an endophytic fungus isolated from its leaves. Organic & Biomolecular Chemistry, 2021, 19 (6), pp.1378-1385. ⟨10.1039/d0ob02443k⟩. ⟨hal-03262416⟩
108 Consultations
86 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More