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Article Dans Une Revue Journal of Bacteriology Année : 2000

Activation of SoxR by Overproduction of Desulfoferrodoxin: Multiple Ways To Induce the soxRS Regulon

Philippe Gaudu

Résumé

ABSTRACT The soxRS response, which protects cells against superoxide toxicity, is triggered by the oxidation of SoxR, a transcription factor. Superoxide excess and NADPH depletion induce the regulon. Unexpectedly, we found that the overproduction of desulfoferrodoxin, a superoxide reductase from sulfate-reducing bacteria, also induced this response. We suggest that desulfoferrodoxin interferes with the reducing pathway that keeps SoxR in its inactive form.

Dates et versions

hal-03258686 , version 1 (11-06-2021)

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Philippe Gaudu, Sarah Dubrac, Danièle Touati. Activation of SoxR by Overproduction of Desulfoferrodoxin: Multiple Ways To Induce the soxRS Regulon. Journal of Bacteriology, 2000, 182 (6), pp.1761-1763. ⟨10.1128/jb.182.6.1761-1763.2000⟩. ⟨hal-03258686⟩
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