Rosetting is associated with increased Plasmodium falciparum in vivo multiplication rate in the Saimiri sciureus monkey - Archive ouverte HAL
Article Dans Une Revue Microbes and Infection Année : 2008

Rosetting is associated with increased Plasmodium falciparum in vivo multiplication rate in the Saimiri sciureus monkey

Résumé

Severe Plasmodium falciparum malaria in African children is associated with high peripheral parasite densities and high rate of rosette-forming parasites. To explore the relationship between rosette formation and parasite density in vivo, we compared the multiplication rate of a rosette-forming variant (varO) of the Palo Alto line with a sibling non-rosetting variant (varR) in splenectomized Saimiri monkeys. The multiplication rate of varO parasites was 1.5-fold higher than that of the varR variant. This indicates that rosetting is indeed associated with high parasite multiplication efficiency in vivo and, as such, may contribute to the high parasite densities observed in severe malaria.

Dates et versions

hal-03253915 , version 1 (08-06-2021)

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Citer

Cécile Le Scanf, Inès Vigan-Womas, Hugues Contamin, Micheline Guillotte, Emmanuel Bischoff, et al.. Rosetting is associated with increased Plasmodium falciparum in vivo multiplication rate in the Saimiri sciureus monkey. Microbes and Infection, 2008, 10 (4), pp.447-451. ⟨10.1016/j.micinf.2007.12.012⟩. ⟨hal-03253915⟩
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