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Article Dans Une Revue Cell Année : 2021

Maturation and persistence of the anti-SARS-CoV-2 memory B cell response

Simon Fillatreau
Felix A. Rey

Résumé

Memory B cells play a fundamental role in host defenses against viruses, but to date, their role has been relatively unsettled in the context of SARS-CoV-2. We report here a longitudinal single-cell and repertoire profiling of the B cell response up to 6 months in mild and severe COVID-19 patients. Distinct SARS-CoV-2 spike-specific activated B cell clones fueled an early antibody-secreting cell burst as well as a durable synchronous germinal center response. While highly mutated memory B cells, including pre-existing cross-reactive seasonal Betacoronavirus-specific clones, were recruited early in the response, neutralizing SARS-CoV-2 RBD-specific clones accumulated with time and largely contributed to the late, remarkably stable, memory B cell pool. Highlighting germinal center maturation, these cells displayed clear accumulation of somatic mutations in their variable region genes over time. Overall, these findings demonstrate that an antigen-driven activation persisted and matured up to 6 months after SARS-CoV-2 infection and may provide long-term protection.
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hal-03253256 , version 1 (10-03-2023)

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Paternité - Pas d'utilisation commerciale

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Aurélien Sokal, Pascal Chappert, Giovanna Barba-Spaeth, Anais Roeser, Slim Fourati, et al.. Maturation and persistence of the anti-SARS-CoV-2 memory B cell response. Cell, 2021, 184 (5), pp.1201-1213.e14. ⟨10.1016/j.cell.2021.01.050⟩. ⟨hal-03253256⟩
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