The sensitivity of turbulent dynamics in spatially evolving mixing layers to small skew angles is investigated via direct numerical simulation. Angle is a measure of the lack of parallelism between the two asymptotic flows, whose interaction creates the turbulent mixing region. The analysis is performed considering a large range of values of the shear intensity parameter . This two-dimensional parameter space is explored using the results of a database of 18 direct numerical simulations. Instantaneous fields as well as time-averaged quantities are investigated, highlighting important mechanisms in the emergence of turbulence and its characteristics for this class of flows. In addition, a stochastic approach is used in which and are considered as random variables with a given probability distribution. The response surfaces of flow statistics in the parameter space are built through non-intrusive generalized polynomial chaos. It is found that variations of the parameter have a primary effect on the growth of the mixing region. A secondary effect associated with is observed as well. Higher values for the skew angle are responsible for a rapid increase in growth of the inlet structures, enhancing the development of the mixing region. The impact on the turbulence features and, in particular, on the Reynolds stress tensor is also significant. A modification of the normalized diagonal components of the Reynolds stress tensor due to is observed. In addition, the interaction between the parameters and is here the governing element.