The study was aimed to model and optimize the removal of cadmium from contaminated post-industrial soil viaSinapis albaL. by comparing two modeling approaches: Response Surface Methodology (RSM) and Artificial Neural Networks (ANN). The experimental design was done using the Box-Behnken Design method. In the RSM model, the quadratic model was shown to predict the closest results in comparison to our experimental data. For ANN approach, a two-layer Feed-Forward Back-Propagation Neural Network model was designed. The results showed that sewage sludge supplementation increased the efficiency of theSinapis albaplant in removing Cd from the soil. After 28 days of exposure, the removal rate varied from 10.96% without any supplementation to 65.9% after supplementation with the highest possible (law allowed) dose of sewage sludge. The comparison proved that the prediction capability of the ANN model was much higher than that of the RSM model (adjustedR-square: 0.98, standard error of the Cd prediction removal: 0.85 +/- 0.02). Thus, the ANN model could be used for the prediction of heavy metal removal during assisted phytoremediation with sewage sludge. Moreover, such approach could also be used to determinate the dose of sewage sludge that will ensure highest process efficiency.