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Article Dans Une Revue Materials Today Bio Année : 2021

3D-printed scaffold combined to 2D osteoinductive coatings to repair a critical-size mandibular bone defect

Résumé

The reconstruction of large bone defects (12 cm3) remains a challenge for clinicians. We developed a new critical-size mandibular bone defect model on a minipig, close to human clinical issues. We analyzed the bone reconstruction obtained by a 3D-printed scaffold made of clinical-grade polylactic acid (PLA), coated with a polyelectrolyte film delivering an osteogenic bioactive molecule (BMP-2). We compared the results (computed tomography scans, microcomputed tomography scans, histology) to the gold standard solution, bone autograft. We demonstrated that the dose of BMP-2 delivered from the scaffold significantly influenced the amount of regenerated bone and the repair kinetics, with a clear BMP-2 dose-dependence. Bone was homogeneously formed inside the scaffold without ectopic bone formation. The bone repair was as good as for the bone autograft. The BMP-2 doses applied in our study were reduced 20- to 75-fold compared to the commercial collagen sponges used in the current clinical applications, without any adverse effects. Three-dimensional printed PLA scaffolds loaded with reduced doses of BMP-2 may be a safe and simple solution for large bone defects faced in the clinic.
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Dates et versions

hal-03247374 , version 1 (07-06-2021)

Identifiants

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M. Bouyer, C. Garot, P. Machillot, J. Vollaire, V. Fitzpatrick, et al.. 3D-printed scaffold combined to 2D osteoinductive coatings to repair a critical-size mandibular bone defect. Materials Today Bio, 2021, 11, pp.100113. ⟨10.1016/j.mtbio.2021.100113⟩. ⟨hal-03247374⟩
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