European cities, like most of the world’s cities, are to some degree dependent upon maritime transport for their development, as more than 90% of seaborne trade volume is carried by sea. This also applies to Europe’s external trade. While cities possessing ports play a crucial role in the distribution of goods traffic in such a context, the maritime influence exerted by global trade on non-port, inland cities have not been so far studied from a combined sea-land perspective. The results show a differentiation of the European territory in terms of modal specialization, core-periphery, polycentricity, and intermodal centrality / accessibility. We map the maritime specialization of European cities in recent decades, showing that combined sea-land centrality has stable but different relationships according to the type of place considered. The conclusion discusses the outcomes of our results for policy and further research on coupled networks and urban studies.