Efficient Access to Arylated Aza‐ullazines by Regioselective Functionalization of their pyridine ring by H‐Li exchange and Electrophilic Substitution.
Résumé
The regioselective functionalization of aza-ullazines has been successfully realized for the first time by either metalation using BuLi-containing aggregates (BuLi-LiDMAE) or electrophilic substitution. Mono and di-bromo-derivatives were obtained in good to
excellent yields and further successfully converted into aryl and alkynyl azaullazine derivatives via Suzuki and Sonogashira crosscoupling reactions.
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