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Transition-Metal-Catalyzed Chiral Amines Synthesis


Chiral amines can be synthesized with high yields and enantioselectivities from abundant organic substrates using transition metal catalytic systems containing most of the time an appropriate chiral bidentate ligand. Reductive amination starts from ketones, hydroamination from alkenes, or alkynes in an inter- or intramolecular mode. In the hydroaminoalkylation reaction, a C–H function in α-position with regard to the nitrogen is activated and forms a new C–C bond. In the hydroaminomethylation, a one-pot carbonylation reaction, the olefin reacts with CO/H2 and amine. Complexes chiral-only-at-metal begin to be efficient to perform the photocatalytic chiral amination under mild conditions. Many recent trends are focused onto first-line transition metals. The major difficulties lie in the synthesis of chiral ligands and the design of a suitable coordination sphere.
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hal-03241440 , version 1 (28-05-2021)



Anton Cunillera, Carmen Claver, Cyril Godard, Martine Urrutigoity, Philippe Kalck. Transition-Metal-Catalyzed Chiral Amines Synthesis. Alfredo Ricci; Luca Bernardi. Methodologies in Amine Synthesis: Challenges and Applications, Wiley-VCH, pp.155-185, 2021, 9783527347391. ⟨10.1002/9783527826186.ch5⟩. ⟨hal-03241440⟩
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