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Communication Dans Un Congrès Année : 2020

Brain response to one?s own name in acute stage coma patients: electroencephalographic detection of cognitive event-related potentials

Résumé

Objective: Patients who have suffered severe brain injuries can show a progressive recovery, from the acute coma to a chronic condition of disorders of consciousness. Event-related potentials (ERPs), like the P3 component, have been successfully used as markers of auditory processing in patients with disorders of consciousness. However, the relevance of the P3 component in acute coma patients remains to be defined. Methods: Using two bedside electroencephalographic recordings 7 days apart (D1 and D8), we acquired in 26 coma patients (traumatic brain injury or anoxia) ERPs to the patient?s own name (versus unfamiliar other first names) after either an excerpt of the patient?s preferred music (music condition, 4 blocks) or a noise (control condition, 4 blocks) presented in an alternating order. Neurological outcome at 3 months was acquired using the Coma Recovery Scale-Revised. Results: In healthy volunteers (n=14), an individual P3 component was systematically observed around 500 msec. In comatose patients, the sensory, earlier, cerebral responses (P1/N1/P2) to the name stimuli was frequently observed. The cognitive P3 response to patient?s own name was observed more often at D8. The link between the detection of these ERPs and a positive prognosis for the patients remains uncertain. Conclusions: Some severely brain-damaged patients in the acute stage of coma are capable of cognitive processing of salient auditory stimuli despite the absence of overt behavioral signs of awareness.
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Dates et versions

hal-03235910 , version 1 (26-05-2021)

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Fabrice Ferré, Alexandra Corneyllie, Edouard Naboulsi, Benjamine Sarton, Fabien Perrin, et al.. Brain response to one?s own name in acute stage coma patients: electroencephalographic detection of cognitive event-related potentials. Forum Acusticum, Dec 2020, Lyon, France. pp.1193-1193, ⟨10.48465/fa.2020.0573⟩. ⟨hal-03235910⟩
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