Article Dans Une Revue Journal of Organic Chemistry Année : 2011

Asymmetric Synthesis of an Antagonist of Neurokinin Receptors: SSR 241586

Résumé

SSR 241586 is a 2,2-disubstituted morpholine, developed by Sanofi-Aventis, which is active in the treatment of schizophrenia and irritable bowel syndrome (IBS). Different strategies have been studied to synthesize this molecule and among the strategies an organo-catalyzed Henry reaction, applied to an α-keto ester, has produced SSR 241586 in excellent enantiomeric excess.

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hal-03228837 , version 1 (18-05-2021)

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Thomas-Xavier Métro, Anne Cochi, Domingo Gomez Pardo, Janine Cossy. Asymmetric Synthesis of an Antagonist of Neurokinin Receptors: SSR 241586. Journal of Organic Chemistry, 2011, 76 (8), pp.2594 - 2602. ⟨10.1021/jo102471r⟩. ⟨hal-03228837⟩
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