Impact of Subthalamic Deep Brain Stimulation on Impulse Control Disorders in Parkinson's Disease: A Prospective Study
Marie Des Neiges Santin
(1)
,
Paul Voulleminot
(1)
,
Agathe Vrillon
(2)
,
Elodie Hainque
(2, 3)
,
Matthieu Bereau
(4)
,
Ouhaid Lagha-Boukbiza
(1)
,
Thomas Wirth
(1)
,
Solveig Montaut
(1)
,
Eric Bardinet
(4, 3)
,
Maéva Kyheng
(5)
,
Anne-Sophie Rolland
(5)
,
Jimmy Voirin
(1)
,
Sophie Drapier
(6)
,
Franck Durif
(7)
,
Alexandre Eusebio
(8, 9)
,
Caroline Giordana
(10)
,
Nicolas Auzou
(11)
,
Jean-Luc Houeto
(12)
,
Cecile Hubsch
(13)
,
Bechir Jarraya
(14, 15)
,
Chloe Laurencin
(16)
,
David Maltete
(17, 18)
,
Mylene Meyer
(19)
,
Olivier Rascol
(20)
,
Tiphaine Rouaud
(21)
,
Fazia Mélissa Tir
(22)
,
Caroline Moreau
(5, 23)
,
Jean-Christophe Corvol
(2, 3)
,
Aurélie Proust
(1)
,
David Grabli
(2)
,
David Devos
(5)
,
Christine Tranchant
(1)
,
Mathieu Anheim
(1)
1
CHU Strasbourg -
Centre Hospitalier Universitaire [Strasbourg]
2 CHU Pitié-Salpêtrière [AP-HP]
3 ICM - Institut du Cerveau = Paris Brain Institute
4 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
5 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
6 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
7 CHU Clermont-Ferrand
8 CHU Marseille
9 INT - Institut de Neurosciences de la Timone
10 CHU Nice - Centre Hospitalier Universitaire de Nice
11 CHU Bordeaux - Centre Hospitalier Universitaire de Bordeaux
12 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
13 Fondation Ophtalmologique Adolphe de Rothschild [Paris]
14 NEUROSPIN - Service NEUROSPIN
15 UVSQ Santé - UFR Sciences de la santé Simone Veil
16 HCL - Hospices Civils de Lyon
17 CHU Rouen
18 DC2N - Différenciation et communication neuronale et neuroendocrine
19 CHU Nancy - Centre Hospitalier Universitaire de Nancy
20 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
21 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
22 CHU Amiens-Picardie
23 LilNCog - Lille Neurosciences & Cognition - U 1172
2 CHU Pitié-Salpêtrière [AP-HP]
3 ICM - Institut du Cerveau = Paris Brain Institute
4 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
5 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
6 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
7 CHU Clermont-Ferrand
8 CHU Marseille
9 INT - Institut de Neurosciences de la Timone
10 CHU Nice - Centre Hospitalier Universitaire de Nice
11 CHU Bordeaux - Centre Hospitalier Universitaire de Bordeaux
12 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
13 Fondation Ophtalmologique Adolphe de Rothschild [Paris]
14 NEUROSPIN - Service NEUROSPIN
15 UVSQ Santé - UFR Sciences de la santé Simone Veil
16 HCL - Hospices Civils de Lyon
17 CHU Rouen
18 DC2N - Différenciation et communication neuronale et neuroendocrine
19 CHU Nancy - Centre Hospitalier Universitaire de Nancy
20 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
21 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
22 CHU Amiens-Picardie
23 LilNCog - Lille Neurosciences & Cognition - U 1172
Marie Des Neiges Santin
Connectez-vous pour contacter l'auteur
- Fonction : Auteur correspondant
- PersonId : 1160129
- ORCID : 0000-0003-2713-2073
- IdRef : 235700363
Connectez-vous pour contacter l'auteur
Maéva Kyheng
- Fonction : Auteur
- PersonId : 1260234
- ORCID : 0000-0002-8915-0915
- IdRef : 250816040
Chloe Laurencin
- Fonction : Auteur
- PersonId : 1254806
- IdHAL : chloe-laurencin
- ORCID : 0000-0002-1516-5401
Olivier Rascol
- Fonction : Auteur
- PersonId : 938353
- ORCID : 0000-0002-1410-6397
- IdRef : 084129980
Fazia Mélissa Tir
- Fonction : Auteur
- PersonId : 1148633
- ORCID : 0000-0001-9147-5519
- IdRef : 091996406
Caroline Moreau
- Fonction : Auteur
- PersonId : 181903
- IdHAL : caroline-moreau
- ORCID : 0000-0002-5503-4078
- IdRef : 129380474
Jean-Christophe Corvol
- Fonction : Auteur
- PersonId : 756631
- ORCID : 0000-0001-7325-0199
- IdRef : 087943492
David Grabli
- Fonction : Auteur
- PersonId : 760487
- ORCID : 0000-0001-6798-4567
David Devos
- Fonction : Auteur
- PersonId : 13309
- IdHAL : david-devos
- ORCID : 0000-0002-2417-799X
- IdRef : 091996309
Résumé
Background Impact of subthalamic deep brain stimulation (DBS) on impulse control disorders (ICD) in Parkinson's disease (PD) remains controversial. Objectives The objectives of this study were to analyze the natural history of ICD between baseline and 1 year after subthalamic DBS in patients with PD and to identify predictive factors, taking into account the positions of the active contact and stimulation parameters. Methods We analyzed postoperative modifications of ICD based on the multicentric, prospective Predictive Factors and Subthalamic Stimulation in Parkinson's Disease cohort. ICD status and Ardouin Scale of Behaviour in PD were assessed at baseline and 1 year following subthalamic DBS. Location of active contacts within the 3 subthalamic nucleus functional territories was investigated. Results A total of 217 were patients included. Of the patients, 10.6% had ICD at baseline of which 95.6% improved at 1 year following subthalamic DBS; 3.6% of the patients experienced de novo ICD at 1 year following subthalamic DBS. Dopamine agonist dose reduction (from 309.8 to 109.3 mg) was the main driver of ICD regression (P= 0.05). Higher preoperative dyskinesias were associated with poorer ICD evolution (P= 0.04). Whereas baseline apathy was a risk factor of de novo ICD (P= 0.02), ICD improvement correlated with postoperative apathy (P= 0.004). Stimulation power and position of active contacts-mainly located within the sensorimotor part of the subthalamic nucleus-did not influence ICD. Conclusions This 1-year, postoperative follow-up study showed ICD regression and dopaminergic drug reduction with optimal position of the active contacts within the subthalamic nucleus. Whereas patients with PD with preoperative ICD were prone to postoperative apathy, we also showed that those with preoperative apathy had a higher risk to experience postoperative de novo ICD, further highlighting the meaningful influence of postoperative management of dopaminergic medication on outcome and the continuum between apathy and ICD. (c) 2020 International Parkinson and Movement Disorder Society