Epimerization-Free C-Term Activation of Peptide Fragments by Ball Milling
Résumé
Peptides were produced in high yields and, if any, very low epimerization, by mechanochemical coupling of peptide fragments containing highly epimerization-prone and/or highly hindered amino acids at C-term. Ball milling was clearly identified as the key element enabling one to obtain such results.
Domaines
Chimie organique
Fichier principal
2021 orglett epimerization free fragment coupling.pdf (869.04 Ko)
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