Atopy Modifies the Association Between Inhaled Corticosteroid Use and Lung Function Decline in Patients with Asthma - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Allergy and Clinical Immunology: In Practice Année : 2019

Atopy Modifies the Association Between Inhaled Corticosteroid Use and Lung Function Decline in Patients with Asthma

Alessandro Marcon
  • Fonction : Auteur correspondant
  • PersonId : 1061112

Connectez-vous pour contacter l'auteur
Pierpaolo Marchetti
  • Fonction : Auteur
Josep María Antó
Lucia Cazzoletti
  • Fonction : Auteur
Isa Cerveri
Angelo Guido Corsico
Diogenes Seraphim Ferreira
Judith Garcia-Aymerich
Davíd Gislason
  • Fonction : Auteur
Joachim Heinrich
  • Fonction : Auteur
Rain Jõgi
  • Fonction : Auteur
Ane Johannessen
Andreï Malinovschi
  • Fonction : Auteur
Isabelle Pin
Nicole M. Probst-Hensch
  • Fonction : Auteur
Joost J.J. Weyler
  • Fonction : Auteur
Christer Janson
Deborah L. Jarvis
  • Fonction : Auteur
Simone Accordini
  • Fonction : Auteur

Résumé

Background: Inhaled corticosteroids (ICSs) are the mainstay of asthma treatment, but response to medication is variable. Patients with allergic inflammation generally show a better short-term response to ICSs; however, studies on predictors of long-term response are few. Objective: To assess whether allergic sensitization can modify the association between ICS use and lung function decline over 20 years in adult asthma. Methods: We used data from the 3 clinical examinations of the European Community Respiratory Health Survey. We measured ICS use (no use, and use for <1.3, 1.3-8, and >8 years) and FEV1 decline among subjects with asthma over the 2 periods between consecutive examinations. We conducted a cohort study combining data of the 2 periods (906 observations from 745 subjects) to assess whether the association between ICS use and FEV1 decline was modified by allergic sensitization (IgE > 0.35 kU/L for any of house-dust mite, timothy grass, cat, or Cladosporium). Results: FEV1 decline was similar for non-ICS users, as well as ICS users for less than 1.3 years, with and without allergic sensitization. However, among subjects on ICSs for a longer period, sensitization was associated with an attenuated decline (Pinteraction = .006): in the group treated for more than 8 years, FEV1 decline was on average 27 mL/y (95% CIBonferroni-adjusted, 11-42) lower for subjects with sensitization compared with nonsensitized subjects. Conclusions: Our study suggests that biomarkers of atopy can predict a more favorable long-term response to ICSs. Randomized controlled studies are needed to confirm these findings.
Fichier principal
Vignette du fichier
1-s2.0-S2213219819309146-main.pdf (1.31 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY NC ND - Paternité - Pas d'utilisation commerciale - Pas de modification

Dates et versions

hal-03227884 , version 1 (07-06-2023)

Identifiants

Citer

Alessandro Marcon, Pierpaolo Marchetti, Josep María Antó, Lucia Cazzoletti, Isa Cerveri, et al.. Atopy Modifies the Association Between Inhaled Corticosteroid Use and Lung Function Decline in Patients with Asthma. Journal of Allergy and Clinical Immunology: In Practice, 2019, 8 (3), pp.980-988.e10. ⟨10.1016/j.jaip.2019.10.023⟩. ⟨hal-03227884⟩
14 Consultations
16 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More