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Article Dans Une Revue Multiple Sclerosis Journal Année : 2021

Determinants of Therapeutic Lag in Multiple Sclerosis

Izanne Roos (1) , Emmanuelle Leray (2, 3, 4, 5, 6, 7) , Federico Frascoli (8) , Romain Casey (9, 10, 11) , J William L Brown (1) , Dana Horakova (12) , Eva Havrdova (12) , Marc Debouverie (13, 14) , Maria Trojano (15) , Francesco Patti (16) , Guillermo Izquierdo Ayuso (17) , Sara Eichau Madueno (16) , Gilles Edan (7, 6) , Alexandre Prat (18) , Marc Girard (18) , Pierre Duquette (18) , Marco Onofrj (19) , Alessandra Lugaresi (19) , Pierre Grammond , Jonathan Ciron (20) , Aurélie Ruet (21, 22) , Serkan Ozakbas (23) , Jerome de Seze (24) , Celine Louapre (25) , Helene Zephir (26) , Maria Jose Sa (27) , Patrizia Sola (28) , Diana Ferraro (29) , Pierre Labauge (30) , Gilles Defer (31) , Roberto Bergamaschi (32) , Christine Lebrun Frenay (32) , Cavit Boz (33) , Elisabetta Cartechini (34) , Thibault Moreau (35) , David A. Laplaud (36, 37) , Jeannette Lechner-Scott (38) , Francois Grand-Maison , Oliver Gerlach (39) , Murat Terzi (40) , Franco Granella (41) , Raed Alroughani (42) , Gerardo Iuliano (43) , Vincent van Pesch (44) , Bart van Wijmeersch (45) , Daniele Litterio A. Spitaleri (46) , Aysun Soysal (47) , Eric Berger (48) , Julie Prévost-Zuddas , Eduardo Aguera-Morales (49) , Pamela Mccombe (50) , Tamara Castillo Triviño (51) , Pierre Clavelou (52) , Jean-Pierre Pelletier (53) , Recai Turkoglu , Bruno Stankoff (25) , Olivier Gout (54) , Eric Thouvenot (55) , Olivier Heinzlef (56) , Youssef Sidhom (57) , Riadh Gouider (57) , Tunde Csepany (58) , Bertrand Bourre (59) , Alkhedr Abdullatif (60) , Olivier Casez (60) , Philippe Cabre (61) , Ivania Patry (62) , Karolina Hankiewicz (63) , Corinne Pottier (64) , Nicolas Maubeuge (65) , Celine Labeyrie (66) , Chantal Nifle (67) , Alasdair Coles (68) , Charles Malpas (1) , Sandra Vukusic (11, 10) , Helmut Butzkueven (69) , Tomas Kalincik (1)
1 University of Melbourne
2 REPERES - Recherche en Pharmaco-épidémiologie et Recours aux Soins
3 EHESP - École des Hautes Études en Santé Publique [EHESP]
4 METIS - Département Méthodes quantitatives en santé publique
5 CoRHASI - Collectif de recherche handicap, autonomie et société inclusive
6 CIC - Centre d'Investigation Clinique [Rennes]
7 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
8 Swinburne University of Technology [Melbourne]
9 UCBL - Université Claude Bernard Lyon 1
10 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
11 HCL - Hospices Civils de Lyon
12 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic]
13 APEMAC - Adaptation, mesure et évaluation en santé. Approches interdisciplinaires
14 Service de neurologie [CHRU Nancy]
15 UNIBA - Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro
16 Unict - Università degli studi di Catania = University of Catania
17 Hospital Virgen Macarena
18 CHUM - Centre Hospitalier de l'Université de Montréal
19 Ud'A - Università degli studi "G. d'Annunzio" Chieti-Pescara [Chieti-Pescara]
20 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
21 U1215 Inserm - UB - Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale
22 CIC Bordeaux
23 DEÜ - Dokuz Eylül Üniversitesi = Dokuz Eylül University [Izmir]
24 Centre d’Investigation Clinique Plurithématique (CIC - P) - CIC Strasbourg
25 ICM - Institut du Cerveau = Paris Brain Institute
26 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
27 Fernando Pessoa University
28 Azienda Ospedaleria Universitaria di Modena
29 UNIMORE - Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia
30 CHU Montpellier
31 CHU Caen
32 CHU Nice - Centre Hospitalier Universitaire de Nice
33 KTU - Karadeniz Technical University
34 UNIMC - Università degli Studi di Macerata = University of Macerata
35 CHU Dijon
36 U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie
37 CHU Nantes - Centre Hospitalier Universitaire de Nantes
38 UoN - University of Newcastle [Callaghan, Australia]
39 Zuyderland Hospital [Heerlen, The Netherlands]
40 OMU - Ondokuz Mayis University
41 UNIPR - Università degli studi di Parma = University of Parma
42 Amiri hospital
43 UNISA - Università degli Studi di Salerno = University of Salerno
44 UCL - Université Catholique de Louvain = Catholic University of Louvain
45 UHasselt - Hasselt University
46 San Giuseppe Moscati Hospital [Avellino, Italie]
47 Bakirkoy Matern & Childrens State Hosp
48 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
49 Universidad de Córdoba = University of Córdoba [Córdoba]
50 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
51 Hospital Donostia
52 CHU Clermont-Ferrand
53 TIMONE - Hôpital de la Timone [CHU - APHM]
54 Fondation Ophtalmologique Adolphe de Rothschild [Paris]
55 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
56 CHI Poissy-Saint-Germain
57 UMA - Université de la Manouba [Tunisie]
58 University of Debrecen Egyetem [Debrecen]
59 Hôpital Charles Nicolle [Rouen]
60 CHU Amiens-Picardie
61 CHU de la Martinique [Fort de France]
62 CHU Limoges
63 CHU Henri Mondor [Créteil]
64 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
65 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
66 Centre Hospitalier Sud Francilien
67 Centre Hospitalier de Saint-Denis [Ile-de-France]
68 Centre Hospitalier René Dubos [Pontoise]
69 Monash University [Clayton]
Pierre Grammond
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Jerome de Seze
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Pierre Labauge
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Gilles Defer
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Thibault Moreau
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Francois Grand-Maison
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Raed Alroughani
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Julie Prévost-Zuddas
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Pierre Clavelou
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Recai Turkoglu
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Bruno Stankoff
Eric Thouvenot
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Ivania Patry
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Tomas Kalincik
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Résumé

Background: A delayed onset of treatment effect, termed therapeutic lag, may influence the assessment of treatment response in some patient subgroups.Objectives: The objective of this study is to explore the associations of patient and disease characteristics with therapeutic lag on relapses and disability accumulation.Methods: Data from MSBase, a multinational multiple sclerosis (MS) registry, and OFSEP, the French MS registry, were used. Patients diagnosed with MS, minimum 1 year of exposure to MS treatment and 3 years of pre-treatment follow-up, were included in the analysis. Studied outcomes were incidence of relapses and disability accumulation. Therapeutic lag was calculated using an objective, validated method in subgroups stratified by patient and disease characteristics. Therapeutic lag under specific circumstances was then estimated in subgroups defined by combinations of clinical and demographic determinants.Results: High baseline disability scores, annualised relapse rate (ARR) ⩾ 1 and male sex were associated with longer therapeutic lag on disability progression in sufficiently populated groups: females with expanded disability status scale (EDSS) < 6 and ARR < 1 had mean lag of 26.6 weeks (95% CI = 18.2-34.9), males with EDSS < 6 and ARR < 1 31.0 weeks (95% CI = 25.3-36.8), females with EDSS < 6 and ARR ⩾ 1 44.8 weeks (95% CI = 24.5-65.1), and females with EDSS ⩾ 6 and ARR < 1 54.3 weeks (95% CI = 47.2-61.5).Conclusions: Pre-treatment EDSS and ARR are the most important determinants of therapeutic lag
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Dates et versions

hal-03223056 , version 1 (20-05-2021)

Identifiants

Citer

Izanne Roos, Emmanuelle Leray, Federico Frascoli, Romain Casey, J William L Brown, et al.. Determinants of Therapeutic Lag in Multiple Sclerosis. Multiple Sclerosis Journal, 2021, 27 (12), pp.1838-1851. ⟨10.1177/1352458520981300⟩. ⟨hal-03223056⟩
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