As the energy transformation in the transportation sector is taking place driven by the development of fuel cell technologies, fuel cell hybrid electric vehicles become promising solutions owing to their long driving duration and zero emissions. However, the unsatisfied lifespan of fuel cells is an inevitable obstacle for their massive commercialization. This paper aims to propose an online adaptive prognostics-based health management strategy for fuel cell hybrid electric vehicles, which can improve the durability of the fuel cell thanks to online health monitoring. Here, particle filtering method is adapted for online fuel cell prognostics and the uncertainty of the predicted results is calculated based on the distribution of particles. A health management strategy is developed based on prognostics and a decision-making process is designed by considering the prognostics uncertainty through a decision fusion method. The obtained results show that the developed strategy has effectively improved the durability of the on-board fuel cell by up to 95.4%. Moreover, a sensitivity analysis of the prognostics occurrence frequency and probability calculation has also been conducted in this paper.