<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03220825</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-15T14:10:49+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open-label, phase 3 trial</title>
            <author role="aut">
              <persName>
                <forename type="first">François</forename>
                <surname>Quénet</surname>
              </persName>
              <idno type="halauthorid">2191812-0</idno>
              <affiliation ref="#struct-229806"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Dominique</forename>
                <surname>Elias</surname>
              </persName>
              <idno type="halauthorid">170628-0</idno>
              <affiliation ref="#struct-156104"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lise</forename>
                <surname>Roca</surname>
              </persName>
              <idno type="halauthorid">1460715-0</idno>
              <affiliation ref="#struct-229806"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Diane</forename>
                <surname>Goéré</surname>
              </persName>
              <idno type="halauthorid">389917-0</idno>
              <affiliation ref="#struct-156104"/>
              <affiliation ref="#struct-467542"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laurent</forename>
                <surname>Ghouti</surname>
              </persName>
              <idno type="halauthorid">1819597-0</idno>
              <affiliation ref="#struct-300075"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marc</forename>
                <surname>Pocard</surname>
              </persName>
              <idno type="halauthorid">16084-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Olivier</forename>
                <surname>Facy</surname>
              </persName>
              <idno type="halauthorid">442657-0</idno>
              <affiliation ref="#struct-74037"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Catherine</forename>
                <surname>Arvieux</surname>
              </persName>
              <email type="md5">a73d76d01b816ee8634f4390e091b940</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="numeric">1289649</idno>
              <idno type="halauthorid" notation="string">1367859-1289649</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6674-799X</idno>
              <idno type="ISNI">http://isni.org/isni/000000035841767X</idno>
              <idno type="IDREF">https://www.idref.fr/059732385</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/AAQ-3128-2021</idno>
              <idno type="VIAF">https://viaf.org/viaf/206970406</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/AAQ-3128-2021</idno>
              <affiliation ref="#struct-257328"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gérard</forename>
                <surname>Lorimier</surname>
              </persName>
              <idno type="halauthorid">563096-0</idno>
              <affiliation ref="#struct-300545"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Denis</forename>
                <surname>Pezet</surname>
              </persName>
              <idno type="halauthorid">740299-0</idno>
              <affiliation ref="#struct-510644"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Frédéric</forename>
                <surname>Marchal</surname>
              </persName>
              <idno type="halauthorid">40263-0</idno>
              <orgName ref="#struct-217752"/>
              <affiliation ref="#struct-357175"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Valeria</forename>
                <surname>Loi</surname>
              </persName>
              <idno type="halauthorid">2204151-0</idno>
              <affiliation ref="#struct-328304"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre</forename>
                <surname>Meeus</surname>
              </persName>
              <idno type="halauthorid">371451-0</idno>
              <affiliation ref="#struct-20549"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Beata</forename>
                <surname>Juzyna</surname>
              </persName>
              <idno type="halauthorid">950627-0</idno>
              <affiliation ref="#struct-502406"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hélène</forename>
                <surname>de Forges</surname>
              </persName>
              <idno type="halauthorid">1428056-0</idno>
              <affiliation ref="#struct-229806"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jacques</forename>
                <surname>Paineau</surname>
              </persName>
              <idno type="halauthorid">2204152-0</idno>
              <affiliation ref="#struct-444080"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Olivier</forename>
                <surname>Glehen</surname>
              </persName>
              <email type="md5">80f6df5931b504c7d43ed22e43bd8c5b</email>
              <email type="domain">chu-lyon.fr</email>
              <idno type="idhal" notation="numeric">1359956</idno>
              <idno type="halauthorid" notation="string">535319-1359956</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2802-4974</idno>
              <idno type="IDREF">https://www.idref.fr/120001845</idno>
              <idno type="VIAF">https://viaf.org/viaf/79249754</idno>
              <idno type="ISNI">http://isni.org/isni/0000000055704233</idno>
              <affiliation ref="#struct-353860"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Accord Elsevier</forename>
                <surname>CCSD</surname>
              </persName>
              <email type="md5">3cc0cc7b8e3329bfb7423fa2578d788e</email>
              <email type="domain">ccsd.cnrs.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2023-02-13 10:43:30</date>
              <date type="whenModified">2026-04-03 16:26:25</date>
              <date type="whenReleased">2023-02-13 10:43:39</date>
              <date type="whenProduced">2021-02</date>
              <date type="whenEndEmbargoed">2022-02-01</date>
              <ref type="file" target="https://hal.science/hal-03220825v1/document">
                <date notBefore="2022-02-01"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-03220825v1/file/S1470204520305994.pdf" id="file-3985045-3475846">
                <date notBefore="2022-02-01"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1081876">
                <persName>
                  <forename>Accord Elsevier</forename>
                  <surname>CCSD</surname>
                </persName>
                <email type="md5">3cc0cc7b8e3329bfb7423fa2578d788e</email>
                <email type="domain">ccsd.cnrs.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03220825</idno>
            <idno type="halUri">https://hal.science/hal-03220825</idno>
            <idno type="halBibtex">quenet:hal-03220825</idno>
            <idno type="halRefHtml">&lt;i&gt;Lancet Oncology&lt;/i&gt;, 2021, 22 (2), pp.256-266. &lt;a target="_blank" href="https://dx.doi.org/10.1016/s1470-2045(20)30599-4"&gt;&amp;#x27E8;10.1016/s1470-2045(20)30599-4&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Lancet Oncology, 2021, 22 (2), pp.256-266. &amp;#x27E8;10.1016/s1470-2045(20)30599-4&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by-nc/4.0/">CC BY-NC 4.0 - Attribution - Non-commercial use<ref corresp="#file-3985045-3475846"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="CHLS" corresp="HCL">Centre Hospitalier Lyon Sud</idno>
            <idno type="stamp" n="FNCLCC" corresp="INSERM">UNICANCER</idno>
            <idno type="stamp" n="VALDAURELLE" corresp="FNCLCC">CRLC Val d'Aurelle - Paul Lamarque</idno>
            <idno type="stamp" n="IGR" corresp="FNCLCC">Institut Gustave Roussy</idno>
            <idno type="stamp" n="VAUTRIN" corresp="FNCLCC">Centre Alexis Vautrin</idno>
            <idno type="stamp" n="ICO" corresp="FNCLCC">Institut de cancérologie de l'Ouest</idno>
            <idno type="stamp" n="PAPIN" corresp="ICO">Centre Paul Papin</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno>
            <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Santé de Sorbonne Université</idno>
            <idno type="stamp" n="SU-MED" corresp="SORBONNE-UNIVERSITE">Médecine - Sorbonne Université</idno>
            <idno type="stamp" n="CHU-CLERMONTFERRAND">CHU DE CLERMONT FERRAND</idno>
            <idno type="stamp" n="TEST-HALCNRS">Collection test HAL CNRS</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="ELSEVIER">Import Elsevier</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open-label, phase 3 trial</title>
                <author role="aut">
                  <persName>
                    <forename type="first">François</forename>
                    <surname>Quénet</surname>
                  </persName>
                  <idno type="halauthorid">2191812-0</idno>
                  <affiliation ref="#struct-229806"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Dominique</forename>
                    <surname>Elias</surname>
                  </persName>
                  <idno type="halauthorid">170628-0</idno>
                  <affiliation ref="#struct-156104"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lise</forename>
                    <surname>Roca</surname>
                  </persName>
                  <idno type="halauthorid">1460715-0</idno>
                  <affiliation ref="#struct-229806"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Diane</forename>
                    <surname>Goéré</surname>
                  </persName>
                  <idno type="halauthorid">389917-0</idno>
                  <affiliation ref="#struct-156104"/>
                  <affiliation ref="#struct-467542"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laurent</forename>
                    <surname>Ghouti</surname>
                  </persName>
                  <idno type="halauthorid">1819597-0</idno>
                  <affiliation ref="#struct-300075"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marc</forename>
                    <surname>Pocard</surname>
                  </persName>
                  <idno type="halauthorid">16084-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Olivier</forename>
                    <surname>Facy</surname>
                  </persName>
                  <idno type="halauthorid">442657-0</idno>
                  <affiliation ref="#struct-74037"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Catherine</forename>
                    <surname>Arvieux</surname>
                  </persName>
                  <email type="md5">a73d76d01b816ee8634f4390e091b940</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">1289649</idno>
                  <idno type="halauthorid" notation="string">1367859-1289649</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6674-799X</idno>
                  <idno type="ISNI">http://isni.org/isni/000000035841767X</idno>
                  <idno type="IDREF">https://www.idref.fr/059732385</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/AAQ-3128-2021</idno>
                  <idno type="VIAF">https://viaf.org/viaf/206970406</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/AAQ-3128-2021</idno>
                  <affiliation ref="#struct-257328"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gérard</forename>
                    <surname>Lorimier</surname>
                  </persName>
                  <idno type="halauthorid">563096-0</idno>
                  <affiliation ref="#struct-300545"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Denis</forename>
                    <surname>Pezet</surname>
                  </persName>
                  <idno type="halauthorid">740299-0</idno>
                  <affiliation ref="#struct-510644"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Frédéric</forename>
                    <surname>Marchal</surname>
                  </persName>
                  <idno type="halauthorid">40263-0</idno>
                  <orgName ref="#struct-217752"/>
                  <affiliation ref="#struct-357175"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Valeria</forename>
                    <surname>Loi</surname>
                  </persName>
                  <idno type="halauthorid">2204151-0</idno>
                  <affiliation ref="#struct-328304"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre</forename>
                    <surname>Meeus</surname>
                  </persName>
                  <idno type="halauthorid">371451-0</idno>
                  <affiliation ref="#struct-20549"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Beata</forename>
                    <surname>Juzyna</surname>
                  </persName>
                  <idno type="halauthorid">950627-0</idno>
                  <affiliation ref="#struct-502406"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hélène</forename>
                    <surname>de Forges</surname>
                  </persName>
                  <idno type="halauthorid">1428056-0</idno>
                  <affiliation ref="#struct-229806"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jacques</forename>
                    <surname>Paineau</surname>
                  </persName>
                  <idno type="halauthorid">2204152-0</idno>
                  <affiliation ref="#struct-444080"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Olivier</forename>
                    <surname>Glehen</surname>
                  </persName>
                  <email type="md5">80f6df5931b504c7d43ed22e43bd8c5b</email>
                  <email type="domain">chu-lyon.fr</email>
                  <idno type="idhal" notation="numeric">1359956</idno>
                  <idno type="halauthorid" notation="string">535319-1359956</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2802-4974</idno>
                  <idno type="IDREF">https://www.idref.fr/120001845</idno>
                  <idno type="VIAF">https://viaf.org/viaf/79249754</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000055704233</idno>
                  <affiliation ref="#struct-353860"/>
                </author>
              </analytic>
              <monogr>
                <idno type="localRef">BioSiS</idno>
                <idno type="halJournalId" status="VALID">17730</idno>
                <idno type="issn">1470-2045</idno>
                <idno type="eissn">1474-5488</idno>
                <title level="j">Lancet Oncology</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">22</biblScope>
                  <biblScope unit="issue">2</biblScope>
                  <biblScope unit="pp">256-266</biblScope>
                  <date type="datePub">2021-02</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/s1470-2045(20)30599-4</idno>
              <idno type="pii">S1470-2045(20)30599-4</idno>
              <idno type="pubmed">33476595</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Background: The addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to cytoreductive surgery has been associated with encouraging survival results in some patients with colorectal peritoneal metastases who were eligible for complete macroscopic resection. We aimed to assess the specific benefit of adding HIPEC to cytoreductive surgery compared with receiving cytoreductive surgery alone.Methods: We did a randomised, open-label, phase 3 trial at 17 cancer centres in France. Eligible patients were aged 18–70 years and had histologically proven colorectal cancer with peritoneal metastases, WHO performance status of 0 or 1, a Peritoneal Cancer Index of 25 or less, and were eligible to receive systemic chemotherapy for 6 months (ie, they had adequate organ function and life expectancy of at least 12 weeks). Patients in whom complete macroscopic resection or surgical resection with less than 1 mm residual tumour tissue was completed were randomly assigned (1:1) to cytoreductive surgery with or without oxaliplatin-based HIPEC. Randomisation was done centrally using minimisation, and stratified by centre, completeness of cytoreduction, number of previous systemic chemotherapy lines, and timing of protocol-mandated systemic chemotherapy. Oxaliplatin HIPEC was administered by the closed (360 mg/m2) or open (460 mg/m2) abdomen techniques, and systemic chemotherapy (400 mg/m2 fluorouracil and 20 mg/m2 folinic acid) was delivered intravenously 20 min before HIPEC. All individuals received systemic chemotherapy (of investigators' choosing) with or without targeted therapy before or after surgery, or both. The primary endpoint was overall survival, which was analysed in the intention-to-treat population. Safety was assessed in all patients who received surgery. This trial is registed with ClinicalTrials.gov, NCT00769405, and is now completed.Findings: Between Feb 11, 2008, and Jan 6, 2014, 265 patients were included and randomly assigned, 133 to the cytoreductive surgery plus HIPEC group and 132 to the cytoreductive surgery alone group. After median follow-up of 63·8 months (IQR 53·0–77·1), median overall survival was 41·7 months (95% CI 36·2–53·8) in the cytoreductive surgery plus HIPEC group and 41·2 months (35·1–49·7) in the cytoreductive surgery group (hazard ratio 1·00 [95·37% CI 0·63–1·58]; stratified log-rank p=0·99). At 30 days, two (2%) treatment-related deaths had occurred in each group.. Grade 3 or worse adverse events at 30 days were similar in frequency between groups (56 [42%] of 133 patients in the cytoreductive surgery plus HIPEC group vs 42 [32%] of 132 patients in the cytoreductive surgery group; p=0·083); however, at 60 days, grade 3 or worse adverse events were more common in the cytoreductive surgery plus HIPEC group (34 [26%] of 131 vs 20 [15%] of 130; p=0·035).Interpretation: Considering the absence of an overall survival benefit after adding HIPEC to cytoreductive surgery and more frequent postoperative late complications with this combination, our data suggest that cytoreductive surgery alone should be the cornerstone of therapeutic strategies with curative intent for colorectal peritoneal metastases.</p>
            </abstract>
            <particDesc>
              <org type="consortium">UNICANCER-GI Group and BIG Renape Group: Pascale Mariani, Cécile Brigand, Jean-Marc Bereder, Simon Msika, Guillaume Portier, Patrick Rat</org>
            </particDesc>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-229806" status="VALID">
          <orgName>UNICANCER - Institut régional du Cancer Montpellier Val d'Aurelle</orgName>
          <orgName type="acronym">ICM</orgName>
          <date type="start">1923-01-01</date>
          <desc>
            <address>
              <addrLine>208, Avenue des ApothicairesParc Euromédecine34298 Montpellier Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.icm.unicancer.fr/fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300222" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-156104" status="VALID">
          <idno type="IdRef">026387433</idno>
          <idno type="ROR">https://ror.org/0321g0743</idno>
          <orgName>Institut Gustave Roussy</orgName>
          <orgName type="acronym">IGR</orgName>
          <desc>
            <address>
              <addrLine>114, rue Édouard-Vaillant 94805 Villejuif Cedex -France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.gustaveroussy.fr/</ref>
          </desc>
        </org>
        <org type="department" xml:id="struct-467542" status="OLD">
          <orgName>Département de chirurgie viscérale  [Gustave Roussy]</orgName>
          <date type="start">2016-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-156104" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300075" status="VALID">
          <orgName>Centre Hospitalier Universitaire de Toulouse</orgName>
          <orgName type="acronym">CHU Toulouse</orgName>
          <desc>
            <address>
              <addrLine>regroupe les hôpitaux  Purpan, Rangueil, Pierre-Paul Riquet, Larey, Paule de Viguier, Hôtel Dieu Saint-Jacques, La Grave, etc.</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-toulouse.fr</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-74037" status="VALID">
          <orgName>Hôpital du Bocage</orgName>
          <desc>
            <address>
              <addrLine>2, boulevard Maréchal-de-Lattre-de-Tassigny, 21000 Dijon</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300924" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-257328" status="VALID">
          <idno type="IdRef">034137076</idno>
          <idno type="ROR">https://ror.org/041rhpw39</idno>
          <orgName>CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble</orgName>
          <orgName type="acronym">CHUGA</orgName>
          <desc>
            <address>
              <addrLine>CS 1021738043 Grenoble cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-300545" status="OLD">
          <orgName>CRLCC - Centre Paul Papin</orgName>
          <orgName type="acronym">CRLCC Paul Papin</orgName>
          <desc>
            <address>
              <addrLine>15 Rue André Boquel, 49055 Angers</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-444080" type="direct"/>
            <relation active="#struct-502406" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-510644" status="OLD">
          <orgName>Hôpital Hôtel-Dieu de Clermont-Ferrand</orgName>
          <date type="end">2009-12-31</date>
          <desc>
            <address>
              <addrLine>13 Bd Charles de Gaulle, 63000 Clermont-Ferrand</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://fr.wikipedia.org/wiki/H%C3%B4tel-Dieu_de_Clermont-Ferrand</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300144" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-357175" status="VALID">
          <idno type="ISNI">0000 0000 8775 4825</idno>
          <idno type="ROR">https://ror.org/00yphhr71</idno>
          <orgName>Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy]</orgName>
          <orgName type="acronym">UNICANCER/ICL</orgName>
          <date type="start">2013-03-01</date>
          <desc>
            <address>
              <addrLine>6 avenue de Bourgogne, 54519 Vandoeuvre les Nancy</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.icl-lorraine.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-502406" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-328304" status="VALID">
          <orgName>CHU Tenon [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>4 Rue de la Chine, 75020 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-tenon-1</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-413221" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-20549" status="VALID">
          <idno type="ROR">https://ror.org/01cmnjq37</idno>
          <orgName>Centre Léon Bérard [Lyon]</orgName>
          <desc>
            <address>
              <addrLine>28, rue Laennec 69373 LYON Cedex 08</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.centreleonberard.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-502406" status="VALID">
          <orgName>UNICANCER</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75654 Paris Cedex 13</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unicancer.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-444080" status="VALID">
          <idno type="ROR">https://ror.org/01m6as704</idno>
          <orgName>Institut de Cancérologie de l'Ouest [Angers/Nantes]</orgName>
          <orgName type="acronym">UNICANCER/ICO</orgName>
          <desc>
            <address>
              <addrLine>15, rue André Boquel - 49055 Angers cedex 02</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.institut-cancerologie-ouest.com/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-502406" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-353860" status="VALID">
          <idno type="ROR">https://ror.org/023xgd207</idno>
          <orgName>Centre Hospitalier Lyon Sud [CHU - HCL]</orgName>
          <orgName type="acronym">CHLS</orgName>
          <desc>
            <address>
              <addrLine>165 Chemin du Grand Revoyet69495 Pierre-Bénite</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/centre-hospitalier-lyon-sud</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300074" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300222" status="VALID">
          <orgName>CRLCC Val d'Aurelle - Paul Lamarque</orgName>
          <desc>
            <address>
              <addrLine>34298 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.valdaurelle.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300924" status="VALID">
          <idno type="ROR">https://ror.org/0377z4z10</idno>
          <orgName>Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand</orgName>
          <orgName type="acronym">CHU Dijon</orgName>
          <desc>
            <address>
              <addrLine>14 rue Paul Gaffarel - 21079 Dijon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-dijon.fr/fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300144" status="VALID">
          <idno type="IdRef">026606836</idno>
          <idno type="ISNI">0000000406394151</idno>
          <idno type="ROR">https://ror.org/02tcf7a68</idno>
          <orgName>CHU Clermont-Ferrand</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-clermontferrand.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300074" status="VALID">
          <idno type="IdRef">026534657</idno>
          <idno type="ROR">https://ror.org/01502ca60</idno>
          <orgName>Hospices Civils de Lyon</orgName>
          <orgName type="acronym">HCL</orgName>
          <desc>
            <address>
              <addrLine>3 Quai des Célestins69002 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>