This research presents the concept of ambiance with its roots in user’s or beholder’s point of view. We believe that in this relation with inhabitant perception, ambiance gathers visible space perception together with layers of invisible space interpretation. Therefore, we introduce Maurice Merleau-Ponty’s idea from L’OEil et l’Esprit (1960) that argues the importance of art experimentation as a form to understand the relation between visible and invisible, and we advocate that art production and art interpretation bring up new space readings that enrich space comprehension beyond the visible and the Cartesian thinking. This paper presents two examples, through a series of works of art: Cartuxa Monastery, Felipe Terzi and Giovanni Casale (1587-1598) and Miguel Bombarda Panoptic Hospital, José Maria Nepomuceno (1892-1896).