Autism is one of the most common developmental disorders in the world. It is defined by inadequate interaction and com- munication. This disorder induces an altered perception. We started from the sources of stress and discomfort in order to create a comforting atmosphere that allows the autistic child to progress in his care center. We so followed a multidisciplinary approach between teams of architects, engineers and child psychiatrists. Our methodology was based on the latest technologies in cognitive science in the capture of the emotional state correlated with the behavioral model, called sensory profile. We aim to propose an architectural space adequate to the sensitive particularities of autistic children in order to guarantee their well-being and comfort.