How to make a little worm pump like a big worm - Archive ouverte HAL Accéder directement au contenu
Autre Publication Scientifique Année : 2020

How to make a little worm pump like a big worm

Résumé

Infections with parasitic helminths expose serious health threats to humans and animals alike. Prevention of disease is dependent on the effective treatment using anthelmintics. Unfortunately, anthelmintic resistance (AR) has evolved in many helminth species during the past decades and meanwhile poses a major constraint to established worm control approaches. This project aimed to improve our understanding of the molecular mechanisms by which helminths, particularly the potentially deadly horse parasite Parascaris sp., become capable of withstanding drug treatment. To this end, Parascaris P-glycoproteins (Pgp), belonging to an important group of mediators of anthelmintic resistance, were introduced into the model organism Caenorhabditis elegans using the CRISPR/Cas9 technology. The resulting transgenic lines will subsequently be analyzed to functionally elucidate the role of putatively AR-associated Parascaris Pgp sequence polymorphisms.
Fichier principal
Vignette du fichier
VonSamson_LeStudiumJournal.pdf (575.01 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03219267 , version 1 (06-05-2021)

Identifiants

Citer

Georg von Samson-Himmelstjerna, Alexander P Gerhard, Jürgen Krücken, Claude L. Charvet, Cédric Neveu, et al.. How to make a little worm pump like a big worm. 2020, pp.8-11. ⟨10.34846/le-studium.206.02.fr.09-2020⟩. ⟨hal-03219267⟩
40 Consultations
18 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More