The design of microstructured chemical products such as emulsions is not a simple task because they are complex systems in which their components, structures, phenomena, and processes are highly interrelated. Any design decision must be made considering its multiple effects on the next stages of the design, production, use, and recycling of the product. The uncertainty and the impact of the decisions are more critical at early design/screening/exploratory stages, when information is scarce and main product characteristics are defined. This study presents an application of a design methodology for early design stages that considers the interrelation between design decisions in oil-in-water (O/W) emulsions. The methodology was explained in detail in the first part of the article containing the conceptual approach. In this second part, the methodology is exemplified through a case study of the cosmetics sector: the design of a moisturizing cream. The case is presented in two parts: first, the decision-making process following the three steps of methodology is explained. Then, the experimental results are presented and discussed. For the case study, the methodology helped to develop five conceptual alternatives of the product based on the use of a nonionic surfactant system, and prototypes were made and tested. It was found that the elements of methodology can be used for the generation of product alternatives that correspond to the design problem.