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Article Dans Une Revue Journal of Medical Microbiology Année : 2009

Reduced susceptibility to amoxicillin of oral streptococci following amoxicillin exposure

Résumé

As antibiotic pressure often triggers bacterial resistance, the use of short-duration therapies is increasingly recommended. The objective of the present study was to evaluate both the clinical efficiency and the impact on oral streptococci of a 3 day versus a 7 day amoxicillin therapy for odontogenic infection requiring tooth extraction. On day 0, patients were randomly assigned to a 3 day or 7 day amoxicillin treatment. The tooth was extracted on day 2 and the post-operative follow-up was carried out on day 9. Oral flora was collected on days 0, 9 and 30, and the susceptibility of the streptococci to amoxicillin was determined. The results showed that treatment with amoxicillin for 3 or 7 days had a similar clinical efficiency, and also induced similar selection of oral streptococci with reduced susceptibility to amoxicillin, suggesting that the selection of strains with reduced susceptibility to amoxicillin is a rapid phenomenon, appearing even with short-duration therapies.

Dates et versions

hal-03216359 , version 1 (04-05-2021)

Identifiants

Citer

H. Chardin, Kazutoyo Yasukawa, N. Nouacer, C. Plainvert, P. Aucouturier, et al.. Reduced susceptibility to amoxicillin of oral streptococci following amoxicillin exposure. Journal of Medical Microbiology, 2009, 58 (8), pp.1092-1097. ⟨10.1099/JMM.0.010207-0⟩. ⟨hal-03216359⟩
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