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Article Dans Une Revue Frontiers in Cell and Developmental Biology Année : 2021

M-Cadherin Is a PAX3 Target During Myotome Patterning

Résumé

PAX3 belongs to the paired-homeobox family of transcription factors and plays a key role as an upstream regulator of muscle progenitor cells during embryonic development. Pax3 -mutant embryos display impaired somite development, yet the consequences for myotome formation have not been characterized. The early myotome is formed by PAX3-expressing myogenic cells that delaminate from the dermomyotomal lips and migrate between the dermomyotome and sclerotome where they terminally differentiate. Here we show that in Pax3 -mutant embryos, myotome formation is impaired, displays a defective basal lamina and the regionalization of the structural protein Desmin is lost. In addition, this phenotype is more severe in embryos combining Pax3 -null and Pax3 dominant-negative alleles. We identify the adhesion molecule M-Cadherin as a PAX3 target gene, the expression of which is modulated in the myotome according to Pax3 gain- and loss-of-function alleles analyzed. Taken together, we identify M-Cadherin as a PAX3-target linked to the formation of the myotome.

Dates et versions

hal-03215051 , version 1 (03-05-2021)

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Citer

Joana Esteves de Lima, Reem Bou Akar, Myriam Mansour, Didier Rocancourt, Margaret Buckingham, et al.. M-Cadherin Is a PAX3 Target During Myotome Patterning. Frontiers in Cell and Developmental Biology, 2021, 9, ⟨10.3389/fcell.2021.652652⟩. ⟨hal-03215051⟩

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