Does Homeostatic Sleep Pressure Buildup Explain Objective Excessive Daytime Sleepiness in Adults With ADHD? An Exploratory Study - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Frontiers in Psychiatry Année : 2021

Does Homeostatic Sleep Pressure Buildup Explain Objective Excessive Daytime Sleepiness in Adults With ADHD? An Exploratory Study

Stephanie Bioulac
  • Fonction : Auteur
Patricia Sagaspe
Eleonore Tron
  • Fonction : Auteur
Christian Berthomier
  • Fonction : Auteur
Marie Brandewinder
  • Fonction : Auteur
Pierre Philip
Jacques Taillard

Résumé

Background: Excessive daytime sleepiness (EDS) is central in Attention deficit hyperactivity disorder (ADHD) but its causes remain unclear. The aim of this study was to explore objective EDS and homeostatic sleep pressure buildup, evaluated by power theta-alpha frequency (PTAF), in drug-free sleepy adults with ADHD and controls. Methods: Participants were placed during a 36-h period of extended wakefulness under constant routine protocol to strictly control sleep time, sleep duration, and circadian zeitgebers. Results: Eight drug-free sleepy patients with ADHD and 7 matched controls were included. The ADHD group had significantly shorter sleep latency on the Maintenance of Wakefulness Test (MWT) throughout extended wakefulness than the control group. There was no significant difference between the groups in PTAF evolution during extended wakefulness and in kinetic sleep pressure buildup, evaluated by the time constant of saturating exponential function. Limitations: The sample was small, so the findings cannot be generalized. Moreover, psychiatric comorbidities and circadian regulation should be taken into account in future studies. Conclusion: In very controlled conditions, mean sleep latency on the MWT during the whole extended wakefulness was significantly shorter in sleepy patients with ADHD than in control subjects. However, the difficulty to remain awake during soporific circumstances observed in these patients with ADHD cannot be explained by changes in the kinetic of sleep pressure buildup. Clinical Trials Registration: www.clinicaltrials.gov/, Identifier: NCT02217371.
Fichier principal
Vignette du fichier
BPH_FP_2021_Bioulac.pdf (370.75 Ko) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03202991 , version 1 (20-04-2021)

Licence

Paternité

Identifiants

Citer

Stephanie Bioulac, Patricia Sagaspe, Eleonore Tron, Antoine Benard, Christian Berthomier, et al.. Does Homeostatic Sleep Pressure Buildup Explain Objective Excessive Daytime Sleepiness in Adults With ADHD? An Exploratory Study. Frontiers in Psychiatry, 2021, 12, pp.586528. ⟨10.3389/fpsyt.2021.586528⟩. ⟨hal-03202991⟩

Collections

U1219
14 Consultations
45 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More