How can we model and design virtual environments to prevent, monitor and avoid automatically major human factors and health issues after intensive care long stay and long-term space flight? Intensive care unit (ICU) and long-term space flight are extreme environments. In both cases it is a risky journey for patients or astronauts that requires life support systems to maintain and protect body integrity, vital functions, sensorimotor and cognitive capacity as stable as possible for post-ICU quality of life recovering or for human outer planet exploration.