Highly Efficient Asymmetric Hydrogenation of Alkyl Aryl Ketones Catalyzed by Iridium Complexes with Chiral Planar Ferrocenyl Phosphino-Thioether Ligands - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Advanced Synthesis and Catalysis Année : 2007

Highly Efficient Asymmetric Hydrogenation of Alkyl Aryl Ketones Catalyzed by Iridium Complexes with Chiral Planar Ferrocenyl Phosphino-Thioether Ligands

Résumé

Iridium complexes of planar‐chiral ferrocenyl phosphine‐thioether ligands were tested in the hydrogenation of simple ketones. Optimization of the conditions led to a highly active catalytic system with turnover numbers up to 915 and turnover frequencies up to ca. 250 h−1. Furthermore, very high enantioselectivities (up to >99 %) together with complete conversions were obtained for the asymmetric hydrogenation of various acetophenones at 10 °C.
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hal-03194673 , version 1 (09-04-2021)

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Erwan Le Roux, Raluca Malacea-Kabbara, Eric Manoury, Rinaldo Poli, Luca Gonsalvi, et al.. Highly Efficient Asymmetric Hydrogenation of Alkyl Aryl Ketones Catalyzed by Iridium Complexes with Chiral Planar Ferrocenyl Phosphino-Thioether Ligands. Advanced Synthesis and Catalysis, 2007, 349 (3), pp.309-313. ⟨10.1002/adsc.200600350⟩. ⟨hal-03194673⟩
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