Highly Efficient Asymmetric Hydrogenation of Alkyl Aryl Ketones Catalyzed by Iridium Complexes with Chiral Planar Ferrocenyl Phosphino-Thioether Ligands
Résumé
Iridium complexes of planar‐chiral ferrocenyl phosphine‐thioether ligands were tested in the hydrogenation of simple ketones. Optimization of the conditions led to a highly active catalytic system with turnover numbers up to 915 and turnover frequencies up to ca. 250 h−1. Furthermore, very high enantioselectivities (up to >99 %) together with complete conversions were obtained for the asymmetric hydrogenation of various acetophenones at 10 °C.
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