Bubble dynamics involved in ultrasonic imaging - Archive ouverte HAL
Article Dans Une Revue Expert Review of Molecular Diagnostics Année : 2006

Bubble dynamics involved in ultrasonic imaging

Résumé

In clinical ultrasound, blood cells cannot be differentiated from surrounding tissue, due to the low acoustic impedance difference between blood cells and their surroundings. Resonant gas bubbles introduced in the blood stream are ideal markers, if rapid dissolution can be prevented. Ultrasound contrast agents consist of microscopically small bubbles encapsulated by an elastic shell. These microbubbles oscillate upon ultrasound insonification. Microbubbles with thin lipid shells have demonstrated highly nonlinear behavior. To enhance diagnostic ultrasound imaging techniques and to explore therapeutic applications, these medical microbubbles have been modeled. Several detection techniques have been proposed to improve the detectability of the microbubbles. A new generation of contrast agents, with special targeting ligands attached to the shells, may assist in imaging nonphysical properties of target tissue. Owing to microbubble-based contrast agents, ultrasound is becoming an even more important technique in clinical diagnostics.
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hal-03193345 , version 1 (11-04-2021)

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Michiel Postema, Georg Schmitz. Bubble dynamics involved in ultrasonic imaging. Expert Review of Molecular Diagnostics, 2006, 6 (3), pp.493-502. ⟨10.1586/14737159.6.3.493⟩. ⟨hal-03193345⟩
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