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Article Dans Une Revue Review of Scientific Instruments Année : 2011

Laser-nucleated acoustic cavitation in focused ultrasound

Résumé

Acoustic cavitation can occur in therapeutic applications of high-amplitude focused ultrasound. Studying acoustic cavitation has been challenging, because the onset of nucleation is unpredictable. We hypothesized that acoustic cavitation can be forced to occur at a specific location using a laser to nucleate a microcavity in a pre-established ultrasound field. In this paper we describe a scientific instrument that is dedicated to this outcome, combining a focused ultrasound transducer with a pulsed laser. We present high-speed photographic observations of laser-induced cavitation and lasernucleated acoustic cavitation, at frame rates of 0.5×10 6 frames per second, from laser pulses of energy above and below the optical breakdown threshold, respectively. Acoustic recordings demonstrated inertial cavitation can be controllably introduced to the ultrasound focus. This technique will contribute to the understanding of cavitation evolution in focused ultrasound including for potential therapeutic applications.
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hal-03193260 , version 1 (11-04-2021)

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Bjoern Gerold, Spiros Kotopoulis, Craig Mcdougall, David Mcgloin, Michiel Postema, et al.. Laser-nucleated acoustic cavitation in focused ultrasound. Review of Scientific Instruments, 2011, 82 (4), pp.044902. ⟨10.1063/1.3579499⟩. ⟨hal-03193260⟩
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