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Article Dans Une Revue Japanese Journal of Applied Physics Année : 2021

Nucleation threshold of carbon black ultrasound contrast agent

Résumé

Most ultrasound contrast agents used in ultrasonic imaging comprise shell-encapsulated microbubbles, whose ingredients have been associated with adverse bioeffects. In this study, we investigated the nucleation behaviour of carbon black dispersion, whose hydrophobic nanoparticles are used intradermally. For a hypothetical, perfectly spherical carbon black particle surrounded by a perfectly spherical gaseous void, we derived a theoretical nucleation threshold of only 1.3× the resting radius. Carbon black particles and aggregates thereof were investigated using high-speed photography during 1.0 MHz sonication. The nucleation threshold found experimentally is lower than the Blake cavitation threshold of 2.0× the resting radius of free, unencapsulated microbubbles. Therefore, carbon black dispersion may be a promising ultrasound contrast agent.
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Dates et versions

hal-03192654 , version 1 (15-04-2021)

Identifiants

Citer

Craig Stuart Carlson, Ryunosuke Matsumoto, Koji Fushino, Miryu Shinzato, Nobuki Kudo, et al.. Nucleation threshold of carbon black ultrasound contrast agent. Japanese Journal of Applied Physics, 2021, Ultrasonic Electronics, 60 (SD), pp.SDDA06. ⟨10.35848/1347-4065/abef0f⟩. ⟨hal-03192654⟩
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