Ultrasound- and microbubble-enhanced chemotherapy for treating pancreatic cancer: a phase I clinical trial - Archive ouverte HAL
Article Dans Une Revue Journal of the Acoustical Society of America Année : 2016

Ultrasound- and microbubble-enhanced chemotherapy for treating pancreatic cancer: a phase I clinical trial

Résumé

Experimental research of ultrasound to induce or improve delivery has snowballed in the past decade. In our work, we investigate the use of low-intensity ultrasound in combination with clinically approved microbubbles to enhance the therapeutic efficacy of chemotherapy. Ten voluntary patients with locally advanced or metastatic pancreatic adenocarcinoma were consecutively recruited. Following standard chemotherapy protocol (intravenous infusion of gemcitabine over 30 min), a clinical ultrasound scanner was targeted at the largest slice of the tumour using modified non-linear contrast imaging settings (1.9 MHz center frequency, 0.27 MPa peak-negative pressure), and SonoVue® was injected intravenously. Ultrasound and microbubble treatment duration was 31.5 min. The combined therapy did not induce any additional toxicity or increase side effect frequency when compared to chemotherapy alone. Combination treated patients were able to tolerate an increased amount treatment cycles when compare historical controls (n = 63); average of 8.3±6.0 cycles, versus 13.8±5.6 cycles. The median survival also increased from 7.0 months to 17.6 months (p = 0.0044). In addition, five patients showed a primary tumor diameter decrease. Combined treatment of ultrasound, microbubbles, and gemcitabine does not increase side effects and may have the potential to increase the therapeutic efficacy of chemotherapy in patients with pancreatic adenocarcinoma.
Fichier non déposé

Dates et versions

hal-03192425 , version 1 (08-04-2021)

Identifiants

Citer

Spiros Kotopoulis, Georg Dimcevski, Emmet Mc Cormack, Michiel Postema, Bjørn Tore Gjertsen, et al.. Ultrasound- and microbubble-enhanced chemotherapy for treating pancreatic cancer: a phase I clinical trial. Journal of the Acoustical Society of America, 2016, Program Abstracts of the 171st Meeting of the Acoustical Society of America, 139 (4), pp.2092. ⟨10.1121/1.4950209⟩. ⟨hal-03192425⟩
50 Consultations
0 Téléchargements

Altmetric

Partager

More