Objective: Eating disorders (ED) are associated with an in increased risk of suicidal behaviours. Laxative abuse might alter the gut-brain axis signaling, that might be implicated in the pathophysiology of suicide. This study aims to determine the association between laxative misuse and suicide attempt (SA) and suicidal ideation (SI) in patients with ED.
Methods: 277 patients with ED were recruited from an Eating Disorder Unit of Lapeyronie Academic Hospital, Montpellier, France. Sociodemographic and clinical data were collected. Chi-square and t test were used, with Bonferroni corrections where required. Multiple regression models assessed the relationships between laxative misuse, SA, and SI.
Results: 62 (22.4%) patients reported lifetime laxative misuse. They were more likely to have a history of SA than non-misusers [43.83 vs 19.9%, p < 0.001, odds ratio (OR) 3.68]. In the multivariate model, adjusted for other confounders, lifetime laxative misuse remained associated with SA (adjusted OR 3.79, p = 0.041). In past 28 days, patients with SA history reported misusing laxatives for more days than patients without SA history (6 vs 1.5 days, p = 0.01, adjusted for vomiting and ED severity). Laxative use days during past 28 days was associated with current SI, adjusted for vomiting in the same period (p = 0.017).
Conclusions: Current and lifetime laxative misuse were associated with SA history and current SI in patients with ED, at least in part independently of other suicide-related factors.
Objective: Eating disorders (ED) are associated with an in increased risk of suicidal behaviours. Laxative abuse might alter the gut-brain axis signaling, that might be implicated in the pathophysiology of suicide. This study aims to determine the association between laxative misuse and suicide attempt (SA) and suicidal ideation (SI) in patients with ED.
Methods: 277 patients with ED were recruited from an Eating Disorder Unit of Lapeyronie Academic Hospital, Montpellier, France. Sociodemographic and clinical data were collected. Chi-square and t test were used, with Bonferroni corrections where required. Multiple regression models assessed the relationships between laxative misuse, SA, and SI.
Results: 62 (22.4%) patients reported lifetime laxative misuse. They were more likely to have a history of SA than non-misusers [43.83 vs 19.9%, p < 0.001, odds ratio (OR) 3.68]. In the multivariate model, adjusted for other confounders, lifetime laxative misuse remained associated with SA (adjusted OR 3.79, p = 0.041). In past 28 days, patients with SA history reported misusing laxatives for more days than patients without SA history (6 vs 1.5 days, p = 0.01, adjusted for vomiting and ED severity). Laxative use days during past 28 days was associated with current SI, adjusted for vomiting in the same period (p = 0.017).
Conclusions: Current and lifetime laxative misuse were associated with SA history and current SI in patients with ED, at least in part independently of other suicide-related factors.
Titre
en
A specific association between laxative misuse and suicidal behaviours in patients with anorexia nervosa and bulimia nervosa
Auteur(s)
Aiste Lengvenyte1, 2, 3
, Robertas Strumila1, 2, 3
, Laurent Maïmoun4, 2, 5
, Maude Seneque1, 6
, Émilie Olié1, 6
, Patrick Lefebvre2
, Eric Renard2, 1
, Philippe Courtet2, 6, 1
, Sebastien Guillaume1, 2, 6
1
IGF -
Institut de Génomique Fonctionnelle
( 1100822 )
- 141, Rue de la Cardonille 34094 Montpellier cedex 5
- France
Institut National de la Santé et de la Recherche Médicale U1191 ( 303623 )
;
Centre National de la Recherche Scientifique UMR5203 ( 441569 )
;
Université de Montpellier ( 1100589 )
2
CHRU Montpellier -
Centre Hospitalier Régional Universitaire [Montpellier]
( 258773 )
- 191 avenue du doyen Gaston Giraud 34295 Montpellier
- France
3
Vilnius University [Vilnius]
( 303686 )
- 3 Universiteto St, LT-01513 Vilnius
- Lituanie
4
PhyMedExp -
Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
( 1100749 )
- 371 Avenue du Doyen G. Giraud, CHU Arnaud de Villeneuve, Bâtiment INSERM Crastes de Paulet - 34295 Montpellier Cedex 5
- France
Institut National de la Santé et de la Recherche Médicale U1046 ( 303623 )
;
Centre National de la Recherche Scientifique UMR9214 ( 441569 )
;
6
CHU Montpellier
( 93599 )
- 371, avenue du Doyen Gaston Giraud 34295 MONTPELLIER cedex 5
- France
Centre Hospitalier Régional Universitaire [Montpellier] ( 258773 )
Licence
Copyright (Tous droits réservés)
Date de publication
2022
Nom de la revue
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity
(ISSN : 1124-4909, ISSN électronique : 1590-1262)
Springer Verlag
Publié par Springer Verlag
https://link.springer.com/journal/40519
Revue non référencée dans Sherpa-Romeo
Aiste Lengvenyte, Robertas Strumila, Laurent Maïmoun, Maude Seneque, Émilie Olié, et al.. A specific association between laxative misuse and suicidal behaviours in patients with anorexia nervosa and bulimia nervosa. Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity, 2022, 27 (1), pp.307-315. ⟨10.1007/s40519-021-01180-x⟩. ⟨hal-03189674⟩