Ultrasound-induced microbubble coalescence by parametric instability - Archive ouverte HAL Accéder directement au contenu
Communication Dans Un Congrès Année : 2003

Ultrasound-induced microbubble coalescence by parametric instability

Résumé

Micrometer-sized gas bubbles in a liquid will oscillate upon insonification by ultrasound. During the expansion phase, bubble coalescence is frequently observed. We give a description of the microbubble coalescence mechanism, based on high-speed optical observations and theoretical modeling.Ultrasound-induced microbubble coalescence is the fusion of two or more microbubbles. As adjacent bubbles expand, the following stages can be distinctly observed: flattening of the bubble surfaces prior to contact, drainage of the interposed liquid film toward a critical thickness, rupture of the liquid film, and formation of a single bubble. Locally the critical thickness is more quickly reached than might be explained from film drainage alone, due to thickness perturbations induced by secondary radiation forces and amplified by a parametric instability. The coalescence process is thus sped up to durations of less than 1 μs for ultrasound contrast agent microbubbles in the micron diameter range.The coalescence mechanism presented here has potential clinical applications in harmonic imaging, noninvasive blood pressure measurements, and targeted drug delivery.
Fichier principal
Vignette du fichier
BME_Twente.pdf (243.66 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03189256 , version 1 (25-10-2022)

Identifiants

Citer

Michiel Postema, Philippe Marmottant, Charles T Lancée, Sascha Hilgenfeldt, Nico de Jong. Ultrasound-induced microbubble coalescence by parametric instability. Proceedings of the 10th Dutch Annual Conference on Biomedical Engineering, 2003, Enschede, Netherlands. pp.177, ⟨10.5281/zenodo.4841069⟩. ⟨hal-03189256⟩
45 Consultations
18 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More