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Article Dans Une Revue Journal of Physical Chemistry Letters Année : 2015

Salt-Induced Universal Slowing Down of the Short-Time Self-Diffusion of a Globular Protein in Aqueous Solution

Marco Grimaldo
  • Fonction : Auteur
Felix Roosen-Runge
Marcus Hennig
  • Fonction : Auteur
Fabio Zanini
  • Fonction : Auteur
Fajun Zhang
Michaela Zamponi
  • Fonction : Auteur
Niina Jalarvo
  • Fonction : Auteur
Frank Schreiber
Tilo Seydel

Résumé

The short-time self-diffusion D of the globular model protein bovine serum albumin in aqueous (D 2O) solutions has been measured comprehensively as a function of the protein and trivalent salt (YCl 3 ) concentration, noted cp and cs , respectively. We observe that D follows a universal master curve D(cs ,cp ) = D(cs = 0,cp ) g(cs /cp ), where D(cs = 0,cp) is the diffusion coefficient in the absence of salt and g(cs/cp ) is a scalar function solely depending on the ratio of the salt and protein concentration. This observation is consistent with a universal scaling of the bonding probability in a picture of cluster formation of patchy particles. The finding corroborates the predictive power of the description of proteins as colloids with distinct attractive ion-activated surface patches.
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Dates et versions

hal-03162925 , version 1 (01-03-2023)

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Citer

Marco Grimaldo, Felix Roosen-Runge, Marcus Hennig, Fabio Zanini, Fajun Zhang, et al.. Salt-Induced Universal Slowing Down of the Short-Time Self-Diffusion of a Globular Protein in Aqueous Solution. Journal of Physical Chemistry Letters, 2015, 6 (13), pp.2577-2582. ⟨10.1021/acs.jpclett.5b01073⟩. ⟨hal-03162925⟩
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