Virtual prototyping and co-simulation of mixed analog/ digital embedded systems have emerged as a promising research topic, in particular for designing medical appliances. In the paper, we show how the integration of different, analog and digital, Models of Computation (MoC) within an UML/SysML based environment, can offer an efficient assistance for designing a cyber-physical system in a progressive and systematic manner. For this, we rely on formal verification and abstract simulation on a high abstraction level, and on Multi-MoC virtual prototyping on a lower abstraction level. A realistic echo monitoring system illustrates (i) the method, (ii) the modeling languages, and (iii) the different verification techniques.