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              <p>This  is  a  quite  a  truism  to  assert  that  scientific  community  has  been for centuries in an hunger for observing life in any of its details, beginning with an anthropomorphized conception of life : Hartsoecker was   seeking   for   germ   of   life   like   homunculi   in   germinal   cells,   nourishing the preformationist theories in developmental biology. For decades,  animalcule  and  manikins  were  sought  with  the  frenzy  and  curiosity of Brobdingnag inhabitants willing to scrutinize Lilliputians' activities.  Frustrations  came  along  with  development  of  microscopy  and  the  restraining  of  "life"  into  smaller  and  smaller  entities,  though  microscopes   had   been   bartered   to   scalpel   in   the   search   of   life's   sparkles.  DNA  was  the  support  of  genetic  data,  inert  as  a  modular  set  of  information  can  be,  around  which  were  dancing  and  swinging  enzymes, assuming transcription and translation of genes into proteins, which  in  turn  were  involved  in  all  the  aspects  of  cell  life  (migration,  proliferation,  differentiation,  death).  Nevertheless,  those  enzymatic  activities  remained  mainly  addressed  in  vitro,  and  characterized  in  context where spatiotemporal patterns of activities were lost : fixed cells enabling snapshots, lysates &amp; fragmented cells. A supplementary level of complexity arose when post-translational modifications of proteins were  found  to  regulate  those  enzymatic  activities.  Still,  cellular  life  in  motion was challenging science to get properly tracked and seen. Single molecules  tracking  seemed  far  out  from  hand  and  life  was  getting  far  from being observed at a glance, discerned by a naked eye.</p>
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