<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03149722</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-15T11:23:40+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Immune Modulation as a Therapeutic Option During the SARS-CoV-2 Outbreak: The Case for Antimalarial Aminoquinolines</title>
            <author role="aut">
              <persName>
                <forename type="first">Joana</forename>
                <surname>Vitte</surname>
              </persName>
              <email type="md5">273bda3345e0e87a6dfdd152b624a638</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">joana-vitte</idno>
              <idno type="idhal" notation="numeric">754717</idno>
              <idno type="halauthorid" notation="string">9390-754717</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/G-2572-2013</idno>
              <idno type="IDREF">https://www.idref.fr/095980806</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3344-9408</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/G-2572-2013</idno>
              <affiliation ref="#struct-1223753"/>
              <affiliation ref="#struct-358615"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Moise</forename>
                <surname>Michel</surname>
              </persName>
              <idno type="halauthorid">2155700-0</idno>
              <affiliation ref="#struct-1223753"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Soraya</forename>
                <surname>Mezouar</surname>
              </persName>
              <email type="md5">d85cbb799d83feadfd13b74d2f19b5b4</email>
              <email type="domain">univ-amu.fr</email>
              <idno type="idhal" notation="string">soraya-mezouar</idno>
              <idno type="idhal" notation="numeric">780881</idno>
              <idno type="halauthorid" notation="string">1120706-780881</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2285-7051</idno>
              <affiliation ref="#struct-358615"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Aissatou Bailo</forename>
                <surname>Diallo</surname>
              </persName>
              <idno type="halauthorid">2156278-0</idno>
              <affiliation ref="#struct-1223753"/>
              <affiliation ref="#struct-358615"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Asma</forename>
                <surname>Boumaza</surname>
              </persName>
              <idno type="halauthorid">1418520-0</idno>
              <affiliation ref="#struct-1223753"/>
              <affiliation ref="#struct-358615"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Louis</forename>
                <surname>Mege</surname>
              </persName>
              <email type="md5">e0bfab9af2e20dce255aa20032e705b6</email>
              <email type="domain">univ-amu.fr</email>
              <idno type="idhal" notation="numeric">932374</idno>
              <idno type="halauthorid" notation="string">670303-932374</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0394-4651</idno>
              <affiliation ref="#struct-1223753"/>
              <affiliation ref="#struct-358615"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Benoit</forename>
                <surname>Desnues</surname>
              </persName>
              <email type="md5">b8f14931850650853bce46a9a05b0291</email>
              <email type="domain">univ-amu.fr</email>
              <idno type="idhal" notation="string">benoit-desnues</idno>
              <idno type="idhal" notation="numeric">172268</idno>
              <idno type="halauthorid" notation="string">11035-172268</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1422-4294</idno>
              <idno type="IDREF">https://www.idref.fr/092143628</idno>
              <affiliation ref="#struct-1223753"/>
              <affiliation ref="#struct-358615"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Julien</forename>
                <surname>Caugant</surname>
              </persName>
              <email type="md5">0ffac29988b2006107b39eecc74efc3b</email>
              <email type="domain">univ-amu.fr</email>
            </editor>
            <funder ref="#projanr-37775"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2023-10-26 13:30:21</date>
              <date type="whenModified">2025-09-18 14:26:35</date>
              <date type="whenReleased">2023-10-26 14:28:45</date>
              <date type="whenProduced">2020</date>
              <date type="whenEndEmbargoed">2023-10-26</date>
              <ref type="file" target="https://amu.hal.science/hal-03149722v1/document">
                <date notBefore="2023-10-26"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://amu.hal.science/hal-03149722v1/file/fimmu-11-02159.pdf" id="file-4260086-3717670">
                <date notBefore="2023-10-26"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484884"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="777481">
                <persName>
                  <forename>Julien</forename>
                  <surname>Caugant</surname>
                </persName>
                <email type="md5">0ffac29988b2006107b39eecc74efc3b</email>
                <email type="domain">univ-amu.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03149722</idno>
            <idno type="halUri">https://amu.hal.science/hal-03149722</idno>
            <idno type="halBibtex">vitte:hal-03149722</idno>
            <idno type="halRefHtml">&lt;i&gt;Frontiers in Immunology&lt;/i&gt;, 2020, 11, &lt;a target="_blank" href="https://dx.doi.org/10.3389/fimmu.2020.02159"&gt;&amp;#x27E8;10.3389/fimmu.2020.02159&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Frontiers in Immunology, 2020, 11, &amp;#x27E8;10.3389/fimmu.2020.02159&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-4260086-3717670"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="IRD">IRD - Institut de recherche pour le développement</idno>
            <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
            <idno type="stamp" n="ANR">ANR</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Immune Modulation as a Therapeutic Option During the SARS-CoV-2 Outbreak: The Case for Antimalarial Aminoquinolines</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Joana</forename>
                    <surname>Vitte</surname>
                  </persName>
                  <email type="md5">273bda3345e0e87a6dfdd152b624a638</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">joana-vitte</idno>
                  <idno type="idhal" notation="numeric">754717</idno>
                  <idno type="halauthorid" notation="string">9390-754717</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/G-2572-2013</idno>
                  <idno type="IDREF">https://www.idref.fr/095980806</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3344-9408</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/G-2572-2013</idno>
                  <affiliation ref="#struct-1223753"/>
                  <affiliation ref="#struct-358615"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Moise</forename>
                    <surname>Michel</surname>
                  </persName>
                  <idno type="halauthorid">2155700-0</idno>
                  <affiliation ref="#struct-1223753"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Soraya</forename>
                    <surname>Mezouar</surname>
                  </persName>
                  <email type="md5">d85cbb799d83feadfd13b74d2f19b5b4</email>
                  <email type="domain">univ-amu.fr</email>
                  <idno type="idhal" notation="string">soraya-mezouar</idno>
                  <idno type="idhal" notation="numeric">780881</idno>
                  <idno type="halauthorid" notation="string">1120706-780881</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2285-7051</idno>
                  <affiliation ref="#struct-358615"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Aissatou Bailo</forename>
                    <surname>Diallo</surname>
                  </persName>
                  <idno type="halauthorid">2156278-0</idno>
                  <affiliation ref="#struct-1223753"/>
                  <affiliation ref="#struct-358615"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Asma</forename>
                    <surname>Boumaza</surname>
                  </persName>
                  <idno type="halauthorid">1418520-0</idno>
                  <affiliation ref="#struct-1223753"/>
                  <affiliation ref="#struct-358615"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Louis</forename>
                    <surname>Mege</surname>
                  </persName>
                  <email type="md5">e0bfab9af2e20dce255aa20032e705b6</email>
                  <email type="domain">univ-amu.fr</email>
                  <idno type="idhal" notation="numeric">932374</idno>
                  <idno type="halauthorid" notation="string">670303-932374</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0394-4651</idno>
                  <affiliation ref="#struct-1223753"/>
                  <affiliation ref="#struct-358615"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Benoit</forename>
                    <surname>Desnues</surname>
                  </persName>
                  <email type="md5">b8f14931850650853bce46a9a05b0291</email>
                  <email type="domain">univ-amu.fr</email>
                  <idno type="idhal" notation="string">benoit-desnues</idno>
                  <idno type="idhal" notation="numeric">172268</idno>
                  <idno type="halauthorid" notation="string">11035-172268</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1422-4294</idno>
                  <idno type="IDREF">https://www.idref.fr/092143628</idno>
                  <affiliation ref="#struct-1223753"/>
                  <affiliation ref="#struct-358615"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">73691</idno>
                <idno type="issn">1664-3224</idno>
                <idno type="eissn">1664-3224</idno>
                <title level="j">Frontiers in Immunology</title>
                <imprint>
                  <publisher>Frontiers</publisher>
                  <biblScope unit="volume">11</biblScope>
                  <date type="datePub">2020</date>
                </imprint>
              </monogr>
              <idno type="doi">10.3389/fimmu.2020.02159</idno>
              <idno type="pubmedcentral">PMC7484884</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">COVID-19</term>
                <term xml:lang="en">SARS-CoV-2</term>
                <term xml:lang="en">chloroquine</term>
                <term xml:lang="en">hydroxychloroquine</term>
                <term xml:lang="en">immune modulation</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The rapid spread, severity, and lack of specific treatment for COVID-19 resulted in hasty drug repurposing. Conceptually, trials of antivirals were well-accepted, but twentieth century antimalarials sparked an impassioned global debate. Notwithstanding, antiviral and immunomodulatory effects of aminoquinolines have been investigatedin vitro, in vivoand in clinical trials for more than 30 years. We review the mechanisms of action of (hydroxy)chloroquine on immune cells and networks and discuss promises and pitfalls in the fight against SARS-CoV-2, the agent of the COVID-19 outbreak.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1223753" status="OLD">
          <idno type="RNSR">201822835X</idno>
          <orgName>Microbes Evolution Phylogénie et Infections</orgName>
          <orgName type="acronym">MEPHI</orgName>
          <date type="start">2019-01-01</date>
          <date type="end">2023-12-31</date>
          <desc>
            <address>
              <addrLine>IHU Méditerranée Infection, 19-21 boulevard Jean Moulin 13005 Marseille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://mephi.eu/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-67872" type="direct"/>
            <relation active="#struct-198056" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-358615" status="VALID">
          <orgName>Institut Hospitalier Universitaire Méditerranée Infection</orgName>
          <orgName type="acronym">IHU Marseille</orgName>
          <date type="start">2011-01-01</date>
          <desc>
            <address>
              <addrLine>IHU - Méditerranée Infection19-21 Bd Jean Moulin13005 MARSEILLE FRANCE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.mediterranee-infection.com/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-67872" status="VALID">
          <idno type="IdRef">050165224</idno>
          <idno type="ROR">https://ror.org/05q3vnk25</idno>
          <orgName>Institut de Recherche pour le Développement</orgName>
          <orgName type="acronym">IRD</orgName>
          <desc>
            <address>
              <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ird.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-198056" status="VALID">
          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <idno type="ROR">https://ror.org/035xkbk20</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-37775" status="VALID">
          <idno type="anr">ANR-10-IAHU-0003</idno>
          <idno type="program">Instituts Hospitalo-Universitaires</idno>
          <orgName>Méditerranée Infection</orgName>
          <desc>I.H.U. Méditerranée Infection</desc>
          <date type="start">2010</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>