<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03148238</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-06T17:41:08+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Characterization of Autozygosity in Pigs in Three-Way Crossbreeding</title>
            <author role="crp">
              <persName>
                <forename type="first">Audrey</forename>
                <surname>Ganteil</surname>
              </persName>
              <email type="md5">15049c26d42bb72a4f8de0acb1f42a50</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="numeric">1272638</idno>
              <idno type="halauthorid" notation="string">1915328-1272638</idno>
              <affiliation ref="#struct-1002449"/>
              <affiliation ref="#struct-1037816"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Silvia Teresa</forename>
                <surname>Rodríguez-Ramilo</surname>
              </persName>
              <email type="md5">f8d2406900250e4cc57eee902330eab0</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">silvia-teresa-rodriguez-ramilo</idno>
              <idno type="idhal" notation="numeric">747687</idno>
              <idno type="halauthorid" notation="string">33531-747687</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7150-0692</idno>
              <orgName ref="#struct-577435"/>
              <affiliation ref="#struct-1002449"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bruno</forename>
                <surname>Ligonesche</surname>
              </persName>
              <idno type="halauthorid">1657093-0</idno>
              <affiliation ref="#struct-1037816"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Catherine</forename>
                <surname>Larzul</surname>
              </persName>
              <email type="md5">ec51df710e190be72cc3ee4e065d4137</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">catherine-larzul</idno>
              <idno type="idhal" notation="numeric">736391</idno>
              <idno type="halauthorid" notation="string">19600-736391</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0533-331X</idno>
              <idno type="IDREF">https://www.idref.fr/167075462</idno>
              <affiliation ref="#struct-1002449"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Catherine</forename>
                <surname>LARZUL</surname>
              </persName>
              <email type="md5">ec51df710e190be72cc3ee4e065d4137</email>
              <email type="domain">inrae.fr</email>
            </editor>
            <funder>French National Research Agency (ANR)2018/0862GDivSelGen (Efficient Use of Genetic Diversity in Genomic Selection, Paris, France) action (INRA SelGen metaprogram)</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2023-07-25 10:23:40</date>
              <date type="whenModified">2026-03-18 14:22:02</date>
              <date type="whenReleased">2023-07-26 11:25:07</date>
              <date type="whenProduced">2021-01-28</date>
              <date type="whenEndEmbargoed">2023-07-25</date>
              <ref type="file" target="https://hal.science/hal-03148238v1/document">
                <date notBefore="2023-07-25"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-03148238v1/file/fgene-11-584556.pdf" id="file-4170125-3633499">
                <date notBefore="2023-07-25"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876413"/>
              <fs>
                <f name="inra_etatDocument_local" notation="string" n="VE">
                  <string>inra_etatDocument_local_VE</string>
                </f>
                <f name="inra_publicVise_local" notation="string" n="SC">
                  <string>inra_publicVise_local_SC</string>
                </f>
              </fs>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="902978">
                <persName>
                  <forename>Catherine</forename>
                  <surname>LARZUL</surname>
                </persName>
                <email type="md5">ec51df710e190be72cc3ee4e065d4137</email>
                <email type="domain">inrae.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03148238</idno>
            <idno type="halUri">https://hal.science/hal-03148238</idno>
            <idno type="halBibtex">ganteil:hal-03148238</idno>
            <idno type="halRefHtml">&lt;i&gt;Frontiers in Genetics&lt;/i&gt;, 2021, 11, &lt;a target="_blank" href="https://dx.doi.org/10.3389/fgene.2020.584556"&gt;&amp;#x27E8;10.3389/fgene.2020.584556&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Frontiers in Genetics, 2021, 11, &amp;#x27E8;10.3389/fgene.2020.584556&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-4170125-3633499"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="ENSA-TOULOUSE">Ecole Nationale Supérieure Agronomique de Toulouse</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="GENETIQUE_ANIMALE">Département GA INRAE</idno>
            <idno type="stamp" n="GENPHYSE">Génétique Physiologie et Systèmes d'Elevage</idno>
            <idno type="stamp" n="INRAEOCCITANIETOULOUSE" corresp="INRAE">INRAE Occitanie Toulouse</idno>
            <idno type="stamp" n="TOULOUSE-INP">Toulouse - INP</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="ENVT">École Nationale Vétérinaire de Toulouse </idno>
            <idno type="stamp" n="EIPURPAN">EIPURPAN</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Characterization of Autozygosity in Pigs in Three-Way Crossbreeding</title>
                <author role="crp">
                  <persName>
                    <forename type="first">Audrey</forename>
                    <surname>Ganteil</surname>
                  </persName>
                  <email type="md5">15049c26d42bb72a4f8de0acb1f42a50</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="numeric">1272638</idno>
                  <idno type="halauthorid" notation="string">1915328-1272638</idno>
                  <affiliation ref="#struct-1002449"/>
                  <affiliation ref="#struct-1037816"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Silvia Teresa</forename>
                    <surname>Rodríguez-Ramilo</surname>
                  </persName>
                  <email type="md5">f8d2406900250e4cc57eee902330eab0</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">silvia-teresa-rodriguez-ramilo</idno>
                  <idno type="idhal" notation="numeric">747687</idno>
                  <idno type="halauthorid" notation="string">33531-747687</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7150-0692</idno>
                  <orgName ref="#struct-577435"/>
                  <affiliation ref="#struct-1002449"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bruno</forename>
                    <surname>Ligonesche</surname>
                  </persName>
                  <idno type="halauthorid">1657093-0</idno>
                  <affiliation ref="#struct-1037816"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Catherine</forename>
                    <surname>Larzul</surname>
                  </persName>
                  <email type="md5">ec51df710e190be72cc3ee4e065d4137</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">catherine-larzul</idno>
                  <idno type="idhal" notation="numeric">736391</idno>
                  <idno type="halauthorid" notation="string">19600-736391</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0533-331X</idno>
                  <idno type="IDREF">https://www.idref.fr/167075462</idno>
                  <affiliation ref="#struct-1002449"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">94054</idno>
                <idno type="issn">1664-8021</idno>
                <title level="j">Frontiers in Genetics</title>
                <imprint>
                  <publisher>Frontiers Media</publisher>
                  <biblScope unit="volume">11</biblScope>
                  <date type="datePub">2021-01-28</date>
                </imprint>
              </monogr>
              <idno type="doi">10.3389/fgene.2020.584556</idno>
              <idno type="pubmed">33584790</idno>
              <idno type="pubmedcentral">PMC7876413</idno>
              <idno type="wos">000616809000001</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">runs of homozygosity</term>
                <term xml:lang="en">genomic inbreeding</term>
                <term xml:lang="en">crossbreeding</term>
                <term xml:lang="en">swine</term>
                <term xml:lang="en">genomic diversity</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.gen.ga">Life Sciences [q-bio]/Genetics/Animal genetics</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Crossbreeding in livestock can be used to increase genetic diversity. The resulting increase in variability is related to the heterozygosity of the crossbred animal. The evolution of diversity during crossbreeding can be assessed using genomic data. The objective of this study was to describe patterns of runs of homozygosity (ROH) in animals resulting from three-way crossbreeding, from parental pure lines, and in their crossbred offspring. The crossbreeding scheme consisted of a first crossbreeding Pietrain boars and Large White sows, after which the offspring of the Pietrain × Large White were crossed with Duroc boars. The offspring of the second crossbreeding are called G0, the offspring of G0 boars and G0 sows are called G1. All the animals were genotyped using the Illumina SNP60 porcine chip. After filtering, analyses were performed with 2,336 animals and 48,579 autosomal single nucleotide polymorphism (SNP). The mean ROH-based inbreeding coefficients were shown to be 0.27 ± 0.05, 0.23 ± 0.04, and 0.26 ± 0.04 for Duroc, Large White, and Pietrain, respectively. ROH were detected in the Pietrain × Large White crossbred but the homozygous segments were fewer and smaller than in their parents. Similar results were obtained in the G0 crossbred. However, in the G1 crossbreds the number and the size of ROH were higher than in G0 parents. Similar ROH hotspots were detected on SSC1, SSC4, SSC7, SSC9, SSC13, SSC14, and SSC15 in both G0 and G1 animals. Long ROH (&gt;16 Mb) were observed in G1 animals, suggesting regions with low recombination rates. The conservation of these homozygous segments in the three crossbred populations means that some haplotypes were shared between parental breeds. Gene annotation in ROH hotspots in G0 animals identified genes related to production traits including carcass composition and reproduction. These findings advance our understanding of how to manage genetic diversity in crossbred populations.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1002449" status="OLD">
          <idno type="RNSR">201421780T</idno>
          <orgName>Génétique Physiologie et Systèmes d'Elevage</orgName>
          <orgName type="acronym">GenPhySE</orgName>
          <date type="start">2020-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>INRAE Auzeville - 24, chemin de Borde-Rouge -Auzeville Tolosane31326 Castanet Tolosan</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://genphyse.toulouse.inra.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300421" type="direct"/>
            <relation active="#struct-448187" type="indirect"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-301264" type="direct"/>
            <relation active="#struct-460848" type="direct"/>
            <relation name="UMR1388" active="#struct-577435" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-1037816" status="INCOMING">
          <orgName>SAS Nucleus</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-1031275" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-300421" status="VALID">
          <idno type="ROR">https://ror.org/03m3gzv89</idno>
          <orgName>École nationale vétérinaire de Toulouse</orgName>
          <orgName type="acronym">ENVT</orgName>
          <desc>
            <address>
              <addrLine>23 chemin des Capelles - 31076 Toulouse Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://envt.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-448187" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-448187" status="VALID">
          <idno type="IdRef">026388820</idno>
          <idno type="ISNI">0000000121766169</idno>
          <idno type="ROR">https://ror.org/033p9g875</idno>
          <orgName>Institut National Polytechnique (Toulouse)</orgName>
          <orgName type="acronym">Toulouse INP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.inp-toulouse.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-301264" status="VALID">
          <idno type="ISNI">0000 0001 2182 8729</idno>
          <idno type="ROR">https://ror.org/03d5w9863</idno>
          <orgName>École nationale supérieure agronomique de Toulouse</orgName>
          <orgName type="acronym">ENSAT, INP-ENSAT, AgroToulouse, INP-AgroToulouse</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ensat.fr/fr/index.html</ref>
          </desc>
          <listRelation>
            <relation active="#struct-448187" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-460848" status="OLD">
          <idno type="ROR">https://ror.org/008bwpw24</idno>
          <orgName>Ecole d'Ingénieurs de Purpan</orgName>
          <orgName type="acronym">INP - PURPAN</orgName>
          <date type="start">2006-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.purpan.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-448187" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-577435" status="VALID">
          <idno type="ROR">https://ror.org/003vg9w96</idno>
          <orgName>Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement</orgName>
          <orgName type="acronym">INRAE</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1031275" status="INCOMING">
          <orgName>Partenaires INRAE</orgName>
          <desc>
            <address>
              <addrLine>Cette structure regroupe l'ensemble des structures créées pour la reprise des données ProdInra</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>