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Article Dans Une Revue Advanced Synthesis and Catalysis Année : 2021

Direct C−H Arylation of Indole‐3‐Acetic Acid Derivatives Enabled by an Autonomous Self‐Optimizing Flow Reactor

Résumé

Described herein is a continuous‐flow strategy for the palladium‐catalyzed direct C−H arylation of indole‐3‐acetic acid derivatives with arenediazonium salts. A fully autonomous self‐optimizing flow platform was used to efficiently optimize the coupling reaction in a three‐dimensional space. The flow methodology developed is experimentally simple, mild, broad in scope, and safer than traditional batch approaches. Our continuous‐flow approach is particularly convenient to prepare precursors of pharmaceutically relevant compounds.
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Dates et versions

hal-03143311 , version 1 (19-02-2021)

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N. Vasudevan, Eric Wimmer, Elvina Barré, Daniel Cortés‐borda, Mireia Rodriguez-Zubiri, et al.. Direct C−H Arylation of Indole‐3‐Acetic Acid Derivatives Enabled by an Autonomous Self‐Optimizing Flow Reactor. Advanced Synthesis and Catalysis, 2021, 363 (3), pp.791-799. ⟨10.1002/adsc.202001217⟩. ⟨hal-03143311⟩
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