Delivery of siRNA by tailored cell-penetrating urea-based foldamers
Résumé
Cell-penetrating foldamers (CPFs) have recently shown promises as efficient and safe nucleic acid delivery systems. However applications of CPFs to siRNA transport remain scarce. Here, we report helical CPFs tailored with specific end-groups (pyridylthio- or n-octyl-ureas) as effective molecular systems in combination with helper lipids to intracellularly deliver biologically-relevant siRNA
Domaines
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