Article Dans Une Revue Chemical Communications Année : 2021

Delivery of siRNA by tailored cell-penetrating urea-based foldamers

Résumé

Cell-penetrating foldamers (CPFs) have recently shown promises as efficient and safe nucleic acid delivery systems. However applications of CPFs to siRNA transport remain scarce. Here, we report helical CPFs tailored with specific end-groups (pyridylthio- or n-octyl-ureas) as effective molecular systems in combination with helper lipids to intracellularly deliver biologically-relevant siRNA

Fichier principal
Vignette du fichier
islandora_112343.pdf (976.65 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)
Licence

Dates et versions

hal-03142297 , version 1 (15-02-2021)

Licence

Identifiants

Citer

Mégane Bornerie, Anaïs Brion, Gilles Guichard, Antoine Kichler, Céline Douat. Delivery of siRNA by tailored cell-penetrating urea-based foldamers. Chemical Communications, 2021, 57 (12), pp.1458-1461. ⟨10.1039/D0CC06285E⟩. ⟨hal-03142297⟩
57 Consultations
178 Téléchargements

Altmetric

Partager

  • More