<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03142227</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-17T04:07:44+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development</title>
            <author role="crp">
              <persName>
                <forename type="first">Mathie</forename>
                <surname>Tenenbaum</surname>
              </persName>
              <email type="md5">ce1b8cf2fd1a01ed514f9f5c5571909d</email>
              <email type="domain">univ-lille.fr</email>
              <idno type="idhal" notation="numeric">1108102</idno>
              <idno type="halauthorid" notation="string">1397064-1108102</idno>
              <affiliation ref="#struct-178275"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Valérie</forename>
                <surname>Plaisance</surname>
              </persName>
              <email type="md5">c852306d1d21c8e11f99d859e79cf790</email>
              <email type="domain">univ-lille.fr</email>
              <idno type="idhal" notation="string">valerie-plaisance</idno>
              <idno type="idhal" notation="numeric">748004</idno>
              <idno type="halauthorid" notation="string">40960-748004</idno>
              <affiliation ref="#struct-178275"/>
              <affiliation ref="#struct-1066983"/>
              <affiliation ref="#struct-1067477"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Raphael</forename>
                <surname>Boutry</surname>
              </persName>
              <idno type="halauthorid">1397062-0</idno>
              <affiliation ref="#struct-178275"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Valérie</forename>
                <surname>Pawlowski</surname>
              </persName>
              <email type="md5">ce5ef56693fb12cb3eff4050d32d37be</email>
              <email type="domain">univ-lille.fr</email>
              <idno type="idhal" notation="string">valeriepawlowski</idno>
              <idno type="idhal" notation="numeric">1298310</idno>
              <idno type="halauthorid" notation="string">1397060-1298310</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7708-7517</idno>
              <affiliation ref="#struct-178275"/>
              <affiliation ref="#struct-1066983"/>
              <affiliation ref="#struct-1067477"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Cécile</forename>
                <surname>Jacovetti</surname>
              </persName>
              <idno type="halauthorid">1499126-0</idno>
              <affiliation ref="#struct-97916"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Clara</forename>
                <surname>Sanchez-Parra</surname>
              </persName>
              <idno type="halauthorid">2151252-0</idno>
              <affiliation ref="#struct-97916"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hélène</forename>
                <surname>Ezanno</surname>
              </persName>
              <idno type="halauthorid">952891-0</idno>
              <affiliation ref="#struct-178275"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Julien</forename>
                <surname>Bourry</surname>
              </persName>
              <idno type="halauthorid">2151253-0</idno>
              <affiliation ref="#struct-178275"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nicole</forename>
                <surname>Beeler</surname>
              </persName>
              <idno type="halauthorid">2151254-0</idno>
              <affiliation ref="#struct-178275"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gianni</forename>
                <surname>Pasquetti</surname>
              </persName>
              <idno type="halauthorid">2151255-0</idno>
              <affiliation ref="#struct-487722"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Valery</forename>
                <surname>Gmyr</surname>
              </persName>
              <idno type="idhal" notation="numeric">800270</idno>
              <idno type="halauthorid" notation="string">1824607-800270</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1236-359X</idno>
              <idno type="IDREF">https://www.idref.fr/122344030</idno>
              <affiliation ref="#struct-487722"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Stéphane</forename>
                <surname>Dalle</surname>
              </persName>
              <email type="md5">3a8dc0a56da53679c6e8aeaa9f5fdcac</email>
              <email type="domain">chu-lyon.fr</email>
              <idno type="idhal" notation="string">stephanedalle</idno>
              <idno type="idhal" notation="numeric">937229</idno>
              <idno type="halauthorid" notation="string">252520-937229</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3423-4548</idno>
              <idno type="IDREF">https://www.idref.fr/075987279</idno>
              <affiliation ref="#struct-1087315"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Julie</forename>
                <surname>Kerr-Conte</surname>
              </persName>
              <idno type="halauthorid">232421-0</idno>
              <affiliation ref="#struct-487722"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">François</forename>
                <surname>Pattou</surname>
              </persName>
              <email type="md5">ce67ab0f13ca6d41a10273b6195ab21b</email>
              <email type="domain">univ-lille.fr</email>
              <idno type="idhal" notation="numeric">758667</idno>
              <idno type="halauthorid" notation="string">229550-758667</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8388-3766</idno>
              <idno type="IDREF">https://www.idref.fr/074750364</idno>
              <affiliation ref="#struct-487722"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Syu-Ichi</forename>
                <surname>Hirai</surname>
              </persName>
              <idno type="halauthorid">234733-0</idno>
              <affiliation ref="#struct-347134"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Romano</forename>
                <surname>Regazzi</surname>
              </persName>
              <idno type="halauthorid">227746-0</idno>
              <affiliation ref="#struct-97916"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Amélie</forename>
                <surname>Bonnefond</surname>
              </persName>
              <email type="md5">33c604acba1b9c8838edeaab6226dcfa</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="string">amelie-bonnefond</idno>
              <idno type="idhal" notation="numeric">1305499</idno>
              <idno type="halauthorid" notation="string">554996-1305499</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9976-3005</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=AKPYcTYAAAAJ</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/O-2784-2017</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/O-2784-2017</idno>
              <affiliation ref="#struct-178275"/>
              <affiliation ref="#struct-69530"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Philippe</forename>
                <surname>Froguel</surname>
              </persName>
              <idno type="halauthorid">154897-0</idno>
              <affiliation ref="#struct-178275"/>
              <affiliation ref="#struct-69530"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Amar</forename>
                <surname>Abderrahmani</surname>
              </persName>
              <email type="md5">47a9dd71fde2d298321c140cebf01636</email>
              <email type="domain">univ-lille.fr</email>
              <idno type="idhal" notation="string">amar-abderrahmani</idno>
              <idno type="idhal" notation="numeric">747981</idno>
              <idno type="halauthorid" notation="string">54353-747981</idno>
              <affiliation ref="#struct-178275"/>
              <affiliation ref="#struct-1066983"/>
              <affiliation ref="#struct-69530"/>
              <affiliation ref="#struct-1067477"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Collection</forename>
                <surname>IEMN</surname>
              </persName>
              <email type="md5">f3c4c8abd4ffdc9885dbd6e4ca535087</email>
              <email type="domain">iemn.fr</email>
            </editor>
            <funder ref="#projanr-37501"/>
            <funder ref="#projeurop-127442"/>
            <funder>This work was supported by grants from “Société Francophone du Diabète (SFD)”, “European Genomic Institute for Diabetes” (E.G.I.D., ANR-10-LABEX-46) and European Commission, European Research Council (GEPIDIAB 294785 to P.F.), and by a grant from the Swiss National Science Foundation (310030-169480 to RR). Human islets were provided by the European Consortium for Islet Transplantation, funded by the Juvenile Diabetes Research Foundation International.</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2021-08-23 19:50:54</date>
              <date type="whenModified">2026-03-23 09:10:02</date>
              <date type="whenReleased">2021-08-24 14:15:20</date>
              <date type="whenProduced">2021-01</date>
              <date type="whenEndEmbargoed">2021-08-23</date>
              <ref type="file" target="https://hal.science/hal-03142227v1/document">
                <date notBefore="2021-08-23"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-03142227v1/file/Tenenbaum2021.pdf" id="file-3324700-2915127">
                <date notBefore="2021-08-23"/>
              </ref>
              <ref type="externalLink" target="https://hal.archives-ouvertes.fr/hal-03142227/file/Tenenbaum2021.pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="102579">
                <persName>
                  <forename>Collection</forename>
                  <surname>IEMN</surname>
                </persName>
                <email type="md5">f3c4c8abd4ffdc9885dbd6e4ca535087</email>
                <email type="domain">iemn.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03142227</idno>
            <idno type="halUri">https://hal.science/hal-03142227</idno>
            <idno type="halBibtex">tenenbaum:hal-03142227</idno>
            <idno type="halRefHtml">&lt;i&gt;Cellular and Molecular Life Sciences&lt;/i&gt;, 2021, 78 (1), pp.287-298. &lt;a target="_blank" href="https://dx.doi.org/10.1007/s00018-020-03499-7"&gt;&amp;#x27E8;10.1007/s00018-020-03499-7&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Cellular and Molecular Life Sciences, 2021, 78 (1), pp.287-298. &amp;#x27E8;10.1007/s00018-020-03499-7&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-3324700-2915127"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="RIIP">Pasteur Network</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-VALENCIENNES">Université de Valenciennes et du Hainaut-Cambresis</idno>
            <idno type="stamp" n="IEMN">Institut d'électronique, de microélectronique et de nanotechnologie</idno>
            <idno type="stamp" n="IGF">Institut de génomique fonctionnelle</idno>
            <idno type="stamp" n="RIIP_LILLE" corresp="RIIP">Institut Pasteur de Lille</idno>
            <idno type="stamp" n="OPENAIRE">OpenAIRE</idno>
            <idno type="stamp" n="BS">Biologie-Santé</idno>
            <idno type="stamp" n="UNIV-MONTPELLIER">Université de Montpellier</idno>
            <idno type="stamp" n="UNIV-LILLE">Université de Lille</idno>
            <idno type="stamp" n="TEST-HALCNRS">Collection test HAL CNRS</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="UM-2015-2021" corresp="UNIV-MONTPELLIER">Université de Montpellier (2015-2021)</idno>
            <idno type="stamp" n="UNIV-CATHOLILLE">Université catholique de Lille</idno>
            <idno type="stamp" n="JUNIA" corresp="UNIV-CATHOLILLE">Junia</idno>
            <idno type="stamp" n="TEST-UPHF">TEST-UPHF</idno>
            <idno type="stamp" n="RTD">Recherche translationnelle sur le diabète</idno>
            <idno type="stamp" n="EGENODIA">Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development</title>
                <author role="crp">
                  <persName>
                    <forename type="first">Mathie</forename>
                    <surname>Tenenbaum</surname>
                  </persName>
                  <email type="md5">ce1b8cf2fd1a01ed514f9f5c5571909d</email>
                  <email type="domain">univ-lille.fr</email>
                  <idno type="idhal" notation="numeric">1108102</idno>
                  <idno type="halauthorid" notation="string">1397064-1108102</idno>
                  <affiliation ref="#struct-178275"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Valérie</forename>
                    <surname>Plaisance</surname>
                  </persName>
                  <email type="md5">c852306d1d21c8e11f99d859e79cf790</email>
                  <email type="domain">univ-lille.fr</email>
                  <idno type="idhal" notation="string">valerie-plaisance</idno>
                  <idno type="idhal" notation="numeric">748004</idno>
                  <idno type="halauthorid" notation="string">40960-748004</idno>
                  <affiliation ref="#struct-178275"/>
                  <affiliation ref="#struct-1066983"/>
                  <affiliation ref="#struct-1067477"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Raphael</forename>
                    <surname>Boutry</surname>
                  </persName>
                  <idno type="halauthorid">1397062-0</idno>
                  <affiliation ref="#struct-178275"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Valérie</forename>
                    <surname>Pawlowski</surname>
                  </persName>
                  <email type="md5">ce5ef56693fb12cb3eff4050d32d37be</email>
                  <email type="domain">univ-lille.fr</email>
                  <idno type="idhal" notation="string">valeriepawlowski</idno>
                  <idno type="idhal" notation="numeric">1298310</idno>
                  <idno type="halauthorid" notation="string">1397060-1298310</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7708-7517</idno>
                  <affiliation ref="#struct-178275"/>
                  <affiliation ref="#struct-1066983"/>
                  <affiliation ref="#struct-1067477"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Cécile</forename>
                    <surname>Jacovetti</surname>
                  </persName>
                  <idno type="halauthorid">1499126-0</idno>
                  <affiliation ref="#struct-97916"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Clara</forename>
                    <surname>Sanchez-Parra</surname>
                  </persName>
                  <idno type="halauthorid">2151252-0</idno>
                  <affiliation ref="#struct-97916"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hélène</forename>
                    <surname>Ezanno</surname>
                  </persName>
                  <idno type="halauthorid">952891-0</idno>
                  <affiliation ref="#struct-178275"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Julien</forename>
                    <surname>Bourry</surname>
                  </persName>
                  <idno type="halauthorid">2151253-0</idno>
                  <affiliation ref="#struct-178275"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nicole</forename>
                    <surname>Beeler</surname>
                  </persName>
                  <idno type="halauthorid">2151254-0</idno>
                  <affiliation ref="#struct-178275"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gianni</forename>
                    <surname>Pasquetti</surname>
                  </persName>
                  <idno type="halauthorid">2151255-0</idno>
                  <affiliation ref="#struct-487722"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Valery</forename>
                    <surname>Gmyr</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">800270</idno>
                  <idno type="halauthorid" notation="string">1824607-800270</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1236-359X</idno>
                  <idno type="IDREF">https://www.idref.fr/122344030</idno>
                  <affiliation ref="#struct-487722"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Stéphane</forename>
                    <surname>Dalle</surname>
                  </persName>
                  <email type="md5">3a8dc0a56da53679c6e8aeaa9f5fdcac</email>
                  <email type="domain">chu-lyon.fr</email>
                  <idno type="idhal" notation="string">stephanedalle</idno>
                  <idno type="idhal" notation="numeric">937229</idno>
                  <idno type="halauthorid" notation="string">252520-937229</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3423-4548</idno>
                  <idno type="IDREF">https://www.idref.fr/075987279</idno>
                  <affiliation ref="#struct-1087315"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Julie</forename>
                    <surname>Kerr-Conte</surname>
                  </persName>
                  <idno type="halauthorid">232421-0</idno>
                  <affiliation ref="#struct-487722"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">François</forename>
                    <surname>Pattou</surname>
                  </persName>
                  <email type="md5">ce67ab0f13ca6d41a10273b6195ab21b</email>
                  <email type="domain">univ-lille.fr</email>
                  <idno type="idhal" notation="numeric">758667</idno>
                  <idno type="halauthorid" notation="string">229550-758667</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8388-3766</idno>
                  <idno type="IDREF">https://www.idref.fr/074750364</idno>
                  <affiliation ref="#struct-487722"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Syu-Ichi</forename>
                    <surname>Hirai</surname>
                  </persName>
                  <idno type="halauthorid">234733-0</idno>
                  <affiliation ref="#struct-347134"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Romano</forename>
                    <surname>Regazzi</surname>
                  </persName>
                  <idno type="halauthorid">227746-0</idno>
                  <affiliation ref="#struct-97916"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Amélie</forename>
                    <surname>Bonnefond</surname>
                  </persName>
                  <email type="md5">33c604acba1b9c8838edeaab6226dcfa</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="string">amelie-bonnefond</idno>
                  <idno type="idhal" notation="numeric">1305499</idno>
                  <idno type="halauthorid" notation="string">554996-1305499</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9976-3005</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=AKPYcTYAAAAJ</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/O-2784-2017</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/O-2784-2017</idno>
                  <affiliation ref="#struct-178275"/>
                  <affiliation ref="#struct-69530"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Philippe</forename>
                    <surname>Froguel</surname>
                  </persName>
                  <idno type="halauthorid">154897-0</idno>
                  <affiliation ref="#struct-178275"/>
                  <affiliation ref="#struct-69530"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Amar</forename>
                    <surname>Abderrahmani</surname>
                  </persName>
                  <email type="md5">47a9dd71fde2d298321c140cebf01636</email>
                  <email type="domain">univ-lille.fr</email>
                  <idno type="idhal" notation="string">amar-abderrahmani</idno>
                  <idno type="idhal" notation="numeric">747981</idno>
                  <idno type="halauthorid" notation="string">54353-747981</idno>
                  <affiliation ref="#struct-178275"/>
                  <affiliation ref="#struct-1066983"/>
                  <affiliation ref="#struct-69530"/>
                  <affiliation ref="#struct-1067477"/>
                </author>
              </analytic>
              <monogr>
                <idno type="localRef">flagship_health</idno>
                <idno type="halJournalId" status="VALID">11568</idno>
                <idno type="issn">1420-682X</idno>
                <idno type="eissn">1420-9071</idno>
                <title level="j">Cellular and Molecular Life Sciences</title>
                <imprint>
                  <publisher>Springer Verlag</publisher>
                  <biblScope unit="volume">78</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">287-298</biblScope>
                  <date type="datePub">2021-01</date>
                  <date type="dateEpub">2020-03-18</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1007/s00018-020-03499-7</idno>
              <idno type="pubmed">32189007</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Postnatal development</term>
                <term xml:lang="en">Pregnancy</term>
                <term xml:lang="en">Obesity</term>
                <term xml:lang="en">Mapk</term>
                <term xml:lang="en">Beta-cell mass</term>
              </keywords>
              <classCode scheme="halDomain" n="spi">Engineering Sciences [physics]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Unveiling the key pathways underlying postnatal beta-cell proliferation can be instrumental to decipher the mechanisms of beta-cell mass plasticity to increased physiological demand of insulin during weight gain and pregnancy. Using transcriptome and global Serine Threonine Kinase activity (STK) analyses of islets from newborn (10 days old) and adult rats, we found that highly proliferative neonatal rat islet cells display a substantially elevated activity of the mitogen activated protein 3 kinase 12, also called dual leucine zipper-bearing kinase (Dlk). As a key upstream component of the c-Jun amino terminal kinase (Jnk) pathway, Dlk overexpression was associated with increased Jnk3 activity and was mainly localized in the beta-cell cytoplasm. We provide the evidence that Dlk associates with and activates Jnk3, and that this cascade stimu- lates the expression of Ccnd1 and Ccnd2, two essential cyclins controlling postnatal beta-cell replication. Silencing of Dlk or of Jnk3 in neonatal islet cells dramatically hampered primary beta-cell replication and the expression of the two cyclins. Moreover, the expression of Dlk, Jnk3, Ccnd1 and Ccnd2 was induced in high replicative islet beta cells from ob/ob mice during weight gain, and from pregnant female rats. In human islets from non-diabetic obese individuals, DLK expression was also cytoplasmic and the rise of the mRNA level was associated with an increase of JNK3, CCND1 and CCND2 mRNA levels, when compared to islets from lean and obese patients with diabetes. In conclusion, we fjnd that activation of Jnk3 signalling by Dlk could be a key mechanism for adapting islet beta-cell mass during postnatal development and weight gain.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-178275" status="VALID">
          <idno type="IdRef">225667754</idno>
          <idno type="ISNI">0000000403706893</idno>
          <idno type="RNSR">200212749D</idno>
          <idno type="ROR">https://ror.org/04k5h2q42</idno>
          <idno type="Wikidata">Q116959521</idno>
          <orgName>Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases  - UMR 8199 - UMR 1283</orgName>
          <orgName type="acronym">EGENODIA (GI3M)</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>(Génomique fonctionnelle (epi) métabolique et mécanismes moléculaires impliqués dans le diabète de type 2 et les maladies associées)- Faculté de Médecine HENRI-WAREMBOURG - Pôle Recherche : 1, place de Verdun –59045 LILLE CEDEX – France*(ancien nom : Génomique Intégrative et Modélisation des Maladies Métaboliques)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://pasteur-lille.fr/centre-de-recherche/unites-de-recherche/epi-genomiques-fonctionnelles-metaboliques-et-mecanismes-moleculaires-impliques-dans-le-diabete-de-type-2-et-les-maladies-associees/</ref>
          </desc>
          <listRelation>
            <relation name="UMR8199" active="#struct-300166" type="direct"/>
            <relation active="#struct-301247" type="indirect"/>
            <relation name="UMR1283" active="#struct-303623" type="direct"/>
            <relation name="UMR8199" active="#struct-374570" type="direct"/>
            <relation name="UMR8199" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1066983" status="VALID">
          <idno type="IdRef">138736421</idno>
          <idno type="ISNI">0000000403683863</idno>
          <idno type="RNSR">199812849E</idno>
          <idno type="ROR">https://ror.org/02q4res37</idno>
          <idno type="Wikidata">Q3151942</idno>
          <orgName>Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520</orgName>
          <orgName type="acronym">IEMN</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>[Univ. Lille, CNRS, Centrale Lille Institut, Junia, Univ. Polytechnique Hauts-de-France] ––Laboratoire Central – Cité Scientifique – Avenue Poincaré – CS 60069 – 59652 VILLENEUVE D’ASCQ CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.iemn.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-120930" type="direct"/>
            <relation active="#struct-374570" type="direct"/>
            <relation name="UMR8520" active="#struct-441569" type="direct"/>
            <relation active="#struct-1001263" type="direct"/>
            <relation active="#struct-1059196" type="direct"/>
            <relation active="#struct-300877" type="indirect"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1067477" status="VALID">
          <idno type="RNSR">199223915J</idno>
          <orgName>NanoBioInterfaces - IEMN</orgName>
          <orgName type="acronym">NBI - IEMN</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Groupe NBI - CCHB IRCICA - 50 Avenue Halley - 59650 Villeneuve d'Ascq</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.iemn.fr/la-recherche/les-groupes/groupe-nbi</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1066983" type="direct"/>
            <relation active="#struct-120930" type="indirect"/>
            <relation active="#struct-374570" type="indirect"/>
            <relation name="UMR8520" active="#struct-441569" type="indirect"/>
            <relation active="#struct-1001263" type="indirect"/>
            <relation active="#struct-1059196" type="indirect"/>
            <relation active="#struct-300877" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-97916" status="VALID">
          <idno type="IdRef">027525031</idno>
          <idno type="ROR">https://ror.org/019whta54</idno>
          <orgName>Université de Lausanne = University of Lausanne</orgName>
          <orgName type="acronym">UNIL</orgName>
          <date type="start">1537-01-01</date>
          <desc>
            <address>
              <addrLine>CH-1015 Lausanne</addrLine>
              <country key="CH"/>
            </address>
            <ref type="url">http://www.hec.unil.ch/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-487722" status="VALID">
          <idno type="IdRef">18838944X</idno>
          <idno type="ISNI">0000 0005 1237 703X</idno>
          <idno type="RNSR">201019111J</idno>
          <idno type="ROR">https://ror.org/03pbmtd68</idno>
          <idno type="Wikidata">Q51783306</idno>
          <orgName>Recherche translationnelle sur le diabète - U 1190</orgName>
          <orgName type="acronym">RTD</orgName>
          <date type="start">2002-01-01</date>
          <desc>
            <address>
              <addrLine>Recherche translationnelle sur le diabète (RTD) - INSERM U1190 -- (Translational Research laboratory for Diabetes - TRD) - faculté de médecine pôle Recherche - 3eme étage ouest - Place de Verdun - 59045 Lille Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://translational-research-diabetes.com/FR/index</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300166" type="direct"/>
            <relation active="#struct-301247" type="indirect"/>
            <relation name="U1190" active="#struct-303623" type="direct"/>
            <relation name="U859" active="#struct-374570" type="direct"/>
            <relation name="U859" active="#struct-425779" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1087315" status="OLD">
          <idno type="ISNI">0000000403832080</idno>
          <idno type="RNSR">200717476V</idno>
          <idno type="ROR">https://ror.org/043wmc583</idno>
          <orgName>Institut de Génomique Fonctionnelle</orgName>
          <orgName type="acronym">IGF</orgName>
          <date type="start">2015-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>141, Rue de la Cardonille 34094 Montpellier cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.igf.cnrs.fr</ref>
          </desc>
          <listRelation>
            <relation name="U1191" active="#struct-303623" type="direct"/>
            <relation active="#struct-410122" type="direct"/>
            <relation name="UMR5203" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-347134" status="VALID">
          <orgName>Wakayama University</orgName>
          <desc>
            <address>
              <country key="JP"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-69530" status="VALID">
          <idno type="ISNI">0000000121138111</idno>
          <idno type="ROR">https://ror.org/041kmwe10</idno>
          <orgName>Imperial College London</orgName>
          <date type="start">1907-01-01</date>
          <desc>
            <address>
              <addrLine>South Kensington Campus, London SW7 2AZ</addrLine>
              <country key="GB"/>
            </address>
            <ref type="url">http://www.imperial.ac.uk/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300166" status="VALID">
          <idno type="ROR">https://ror.org/05k9skc85</idno>
          <orgName>Institut Pasteur de Lille</orgName>
          <date type="start">1894</date>
          <desc>
            <address>
              <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.pasteur-lille.fr/accueil/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301247" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301247" status="VALID">
          <orgName>Pasteur Network (Réseau International des Instituts Pasteur)</orgName>
          <desc>
            <address>
              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://pasteur-network.org/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-374570" status="VALID">
          <idno type="IdRef">223446556</idno>
          <idno type="ISNI">0000 0001 2242 6780</idno>
          <idno type="ROR">https://ror.org/02kzqn938</idno>
          <idno type="Wikidata">Q3551621</idno>
          <orgName>Université de Lille</orgName>
          <desc>
            <address>
              <addrLine>EPE Université de Lille. -- 42 rue Paul Duez, 59000 Lille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-120930" status="VALID">
          <idno type="IdRef">256304629</idno>
          <idno type="ISNI">0000000122034461</idno>
          <idno type="ROR">https://ror.org/01x441g73</idno>
          <orgName>Centrale Lille</orgName>
          <desc>
            <address>
              <addrLine>École Centrale de Lille - Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://centralelille.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1001263" status="VALID">
          <idno type="IdRef">242335675</idno>
          <idno type="ROR">https://ror.org/02ezch769</idno>
          <orgName>Université Polytechnique Hauts-de-France</orgName>
          <orgName type="acronym">UPHF</orgName>
          <date type="start">2019-09-09</date>
          <desc>
            <address>
              <addrLine>Campus Mont Houy59313 Valenciennes Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.uphf.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1059196" status="VALID">
          <idno type="IdRef">258598026</idno>
          <idno type="ROR">https://ror.org/02evec030</idno>
          <orgName>JUNIA</orgName>
          <orgName type="acronym">JUNIA</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>2 Rue Norbert Segard59014 Lille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.junia.com/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300877" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300877" status="VALID">
          <idno type="IdRef">026582481</idno>
          <idno type="ROR">https://ror.org/025s1b152</idno>
          <orgName>Université catholique de Lille</orgName>
          <orgName type="acronym">UCL</orgName>
          <desc>
            <address>
              <addrLine>60 boulevard Vauban - 59800 Lille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-catholille.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-425779" status="VALID">
          <idno type="IdRef">034424636</idno>
          <idno type="ISNI">0000000404718845</idno>
          <idno type="ROR">https://ror.org/02ppyfa04</idno>
          <idno type="Wikidata">Q2945741</idno>
          <orgName>Centre Hospitalier Régional Universitaire [CHU Lille]</orgName>
          <orgName type="acronym">CHRU Lille</orgName>
          <desc>
            <address>
              <addrLine>CHU/CHRU Lille - 2, avenue Oscar Lambret - 59037 Lille Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chru-lille.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-410122" status="OLD">
          <idno type="ISNI">0000000120970141</idno>
          <idno type="ROR">https://ror.org/051escj72</idno>
          <orgName>Université de Montpellier</orgName>
          <orgName type="acronym">UM</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.umontpellier.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-37501" status="VALID">
          <idno type="anr">ANR-10-LABX-0046</idno>
          <orgName>EGID</orgName>
          <desc>EGID Diabetes Pole</desc>
          <date type="start">2010</date>
        </org>
        <org type="europeanProject" xml:id="projeurop-127442" status="VALID">
          <idno type="number">294785</idno>
          <idno type="program">ERC-2011-ADG_20110310</idno>
          <idno type="call">ERC-2011-ADG_20110310</idno>
          <orgName>GEPIDIAB</orgName>
          <desc>Genetics and epigenetics of Type 2 Diabetes physiology</desc>
          <date type="start">2012-01-11</date>
          <date type="end">2017-10-31</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>