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Journal Articles Coordination Chemistry Reviews Year : 2021

Dendritic metal complexes for bioimaging. Recent advances


Dendrimers are hyperbranched macromolecules, having a large number of terminal functions, easily accessible and modifiable to afford the desired properties. Metal complexes of dendrimers are frequently used as catalysts in diverse reactions, but they can be used also as innovative biological tools. This review focusses on the recent advances (last 10 years) of dendritic metal complexes used for bioimaging, essentially in vivo. Three main domains will be covered. The first one concerns luminescent complexes for optical imaging (OI). The second one is the largest one; it concerns magnetic resonance imaging (MRI) contrast agents, mostly based on gadolinium complexes. The third and last domain concerns radioactive dendrimer complexes for single photon emission computed tomography (SPECT), and also for positron emission tomography (PET). Two main radionucleides are used in this context, technetium (99m Tc) and indium (111 In). Two types of ligands are generally used for all these complexes in the two last domains, diethylenetriaminepentaacetic acid (DTPA), and a cyclic analogue, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), and some of their derivatives. These complexes have been used in many cases for in vivo imaging of cancerous tumors in mice or rats.
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hal-03131731 , version 1 (04-02-2021)


  • HAL Id : hal-03131731 , version 1


Anne-Marie Caminade, Aurélien Hameau, Cédric-Olivier Turrin, Regis Laurent, Jean Pierre Majoral. Dendritic metal complexes for bioimaging. Recent advances. Coordination Chemistry Reviews, 2021, 430, pp.213739. ⟨hal-03131731⟩
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